Wang Yixue, Sun Hongru, Li Gen, Xu Jingxue, Wang Siyu, Zhang Shijie, Zhou Tianle, Han Tianshu, Sun Changhao, Ma Jianqun, Wang Xiaoyuan, Yin Hang
Department of Thoracic Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China.
Department of Epidemiology, Public Health College, Harbin Medical University, Harbin, Heilongjiang, China.
Nat Commun. 2025 Jan 22;16(1):938. doi: 10.1038/s41467-025-56252-8.
Numerous risk factors for oesophageal cancer are linked to lifestyle habits, but the role of early-life factors in its incidence and mortality is unclear. Using UK Biobank data, we explore the association among breastfeeding, maternal smoking, smoking in offspring, and oesophageal cancer risk in adult offspring via multivariable Cox regression. Here, we show that being breastfed, compared with not being breastfed, is associated with a lower risk of oesophageal cancer incidence (HR: 0.83, 95% CI: 0.70-0.98) and mortality (HR: 0.74, 95% CI: 0.61-0.89) in adult offspring. Additionally, it is associated with a reduced impact of smoking in offspring on oesophageal cancer incidence (HR: 0.79, 95% CI: 0.64-0.96) and mortality (HR: 0.73, 95% CI: 0.59-0.91). We subsequently construct a polygenic risk score for oesophageal cancer to explore the influence of genetic factors. Our findings emphasize the importance of breastfeeding, and smoking cessation to prevent oesophageal cancer.
食管癌的众多风险因素与生活习惯有关，但早期生活因素在其发病率和死亡率中的作用尚不清楚。利用英国生物银行的数据，我们通过多变量Cox回归探讨了母乳喂养、母亲吸烟、后代吸烟与成年后代患食管癌风险之间的关联。在此，我们表明，与未进行母乳喂养相比，母乳喂养与成年后代患食管癌的较低风险相关（风险比：0.83，95%置信区间：0.70 - 0.98）以及死亡率（风险比：0.74，95%置信区间：0.61 - 0.89）。此外，它还与后代吸烟对食管癌发病率（风险比：0.79，95%置信区间：0.64 - 0.96）和死亡率（风险比：0.73，95%置信区间：0.59 - 0.91）的影响降低有关。我们随后构建了一个食管癌的多基因风险评分，以探讨遗传因素的影响。我们的研究结果强调了母乳喂养和戒烟对预防食管癌的重要性。
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