Department of Twin Research & Genetic Epidemiology, King's College London, St Thomas Hospital, Westminster Bridge Road, London SE1 7EH, UK.
Department of Twin Research & Genetic Epidemiology, King's College London, St Thomas Hospital, Westminster Bridge Road, London SE1 7EH, UK; Center for Biostatistics, Epidemiology, and Public Health, Department of Clinical and Biological Sciences, University of Turin, Turin, Italy.
Cell Rep. 2024 Feb 27;43(2):113728. doi: 10.1016/j.celrep.2024.113728. Epub 2024 Jan 31.
Cardiometabolic diseases are leading causes of mortality in Western countries. Well-established risk factors include host genetics, lifestyle, diet, and the gut microbiome. Moreover, gut bacterial communities and their activities can be altered by bacteriophages (also known simply as phages), bacteria-infecting viruses, making these biological entities key regulators of human cardiometabolic health. The manipulation of bacterial populations by phages enables the possibility of using phages in the treatment of cardiometabolic diseases through phage therapy and fecal viral transplants. First, however, a deeper understanding of the role of the phageome in cardiometabolic diseases is required. In this review, we first introduce the phageome as a component of the gut microbiome and discuss fecal viral transplants and phage therapy in relation to cardiometabolic diseases. We then summarize the current state of phageome research in cardiometabolic diseases and propose how the phageome might indirectly influence cardiometabolic health through gut bacteria and their metabolites.
心血管代谢疾病是西方国家主要的死亡原因。公认的风险因素包括宿主遗传、生活方式、饮食和肠道微生物组。此外，噬菌体（也称为噬菌体）可改变肠道细菌群落及其活性，使这些生物实体成为人类心血管代谢健康的关键调节剂。噬菌体对细菌种群的操纵使得通过噬菌体治疗和粪便病毒移植来治疗心血管代谢疾病成为可能。然而，首先需要更深入地了解噬菌体组在心血管代谢疾病中的作用。在这篇综述中，我们首先将噬菌体组作为肠道微生物组的一个组成部分进行介绍，并讨论粪便病毒移植和噬菌体治疗与心血管代谢疾病的关系。然后，我们总结了心血管代谢疾病中噬菌体组研究的现状，并提出了噬菌体组如何通过肠道细菌及其代谢物间接影响心血管代谢健康。
