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Reply to "Concerns regarding the interpretation of Shank3 protein isoforms expressed in Shank3B mice: potential off-target effects by a neomycin resistance cassette".

作者信息

Wang Yi-Zhi, Savas Jeffrey N

机构信息

Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.

出版信息

Mol Psychiatry. 2025 Apr;30(4):1712-1713. doi: 10.1038/s41380-025-02903-7. Epub 2025 Jan 22.

DOI:10.1038/s41380-025-02903-7
PMID:39843547
Abstract
摘要

相似文献

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Reply to "Concerns regarding the interpretation of Shank3 protein isoforms expressed in Shank3B mice: potential off-target effects by a neomycin resistance cassette".对《关于Shank3B小鼠中表达的Shank3蛋白亚型的解读:新霉素抗性盒的潜在脱靶效应》的回复
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The Neomycin Resistance Cassette in the Targeted Allele of Knock-Out Mice Has Potential Off-Target Effects to Produce an Unusual Shank3 Isoform.基因敲除小鼠靶向等位基因中的新霉素抗性盒具有产生异常Shank3异构体的潜在脱靶效应。
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3
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本文引用的文献

1
Neuron type-specific proteomics reveals distinct Shank3 proteoforms in iSPNs and dSPNs lead to striatal synaptopathy in Shank3B mice.神经元类型特异性蛋白质组学揭示 iSPNs 和 dSPNs 中独特的 Shank3 蛋白形式,导致 Shank3B 小鼠纹状体突触病变。
Mol Psychiatry. 2024 Aug;29(8):2372-2388. doi: 10.1038/s41380-024-02493-w. Epub 2024 Mar 14.
2
Upregulation of SYNGAP1 expression in mice and human neurons by redirecting alternative splicing.通过重排选择性剪接上调小鼠和人神经元中的 SYNGAP1 表达。
Neuron. 2023 May 17;111(10):1637-1650.e5. doi: 10.1016/j.neuron.2023.02.021. Epub 2023 Mar 13.
3
The Neomycin Resistance Cassette in the Targeted Allele of Knock-Out Mice Has Potential Off-Target Effects to Produce an Unusual Shank3 Isoform.
基因敲除小鼠靶向等位基因中的新霉素抗性盒具有产生异常Shank3异构体的潜在脱靶效应。
Front Mol Neurosci. 2021 Jan 11;13:614435. doi: 10.3389/fnmol.2020.614435. eCollection 2020.
4
SynGAP isoforms differentially regulate synaptic plasticity and dendritic development.突触 GAP 同型物调节突触可塑性和树突发育的功能分化。
Elife. 2020 Jun 24;9:e56273. doi: 10.7554/eLife.56273.
5
Unexpected Compensatory Increase in Transcripts in Knock-Out Mice Having Partial Deletions of Exons.外显子部分缺失的基因敲除小鼠中转录本意外的代偿性增加。
Front Mol Neurosci. 2019 Sep 19;12:228. doi: 10.3389/fnmol.2019.00228. eCollection 2019.
6
Synaptic Neurexin Complexes: A Molecular Code for the Logic of Neural Circuits.突触神经连接蛋白复合体:神经回路逻辑的分子编码
Cell. 2017 Nov 2;171(4):745-769. doi: 10.1016/j.cell.2017.10.024.
7
SHANK proteins: roles at the synapse and in autism spectrum disorder.SHANK 蛋白:在突触和自闭症谱系障碍中的作用。
Nat Rev Neurosci. 2017 Mar;18(3):147-157. doi: 10.1038/nrn.2016.183. Epub 2017 Feb 9.
8
Modeling autism by SHANK gene mutations in mice.在小鼠中通过 SHANK 基因突变建模自闭症。
Neuron. 2013 Apr 10;78(1):8-27. doi: 10.1016/j.neuron.2013.03.016.
9
SynGAP isoforms exert opposing effects on synaptic strength.SynGAP 异构体对突触强度产生相反的影响。
Nat Commun. 2012 Jun 12;3:900. doi: 10.1038/ncomms1900.
10
Shank3 mutant mice display autistic-like behaviours and striatal dysfunction.Shank3 突变小鼠表现出自闭症样行为和纹状体功能障碍。
Nature. 2011 Apr 28;472(7344):437-42. doi: 10.1038/nature09965. Epub 2011 Mar 20.