Zhong Lingzhi, Li Tingting, Zhang Xiaoyue, Li Houmin
Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, People's Republic of China.
Peking University First Hospital, Beijing, China.
Mycopathologia. 2025 Jan 23;190(1):18. doi: 10.1007/s11046-024-00923-5.
Interdigital tinea pedis is a common type of tinea pedis that occurs between toes and is easy to recur. Recently, the skin microbiome analysis of interdigital tinea pedis showed changes in bacterial microbiome in addition to fungal infection.
To investigate the efficacy and safety of clioquinol 3% cream in treating interdigital tinea pedis as well as characterize changes in the skin microbiome during treatment.
The clinical characteristics and skin microbiome of patients with interdigital tinea pedis were investigated in a longitudinal prospective study. In total 28 participants were rcruited to use the clioquinol 3% cream topically to the target skin lesions twice a day for 1 week. Disease severity evaluation, fungal microscopic examination, and sample collection for skin microbiome analysis were performed at baseline, after treatment, and 1 week post-treatment.
Compared with baseline, the disease severity, lesion score, pruritus score, and malodor score of the patients significantly decreased after treatment and at 1 week post-treatment (P < 0.05). The fungal profiles after treatment and 1 week post-treatment revealed significantly decreased abundance of Trichophyton and significantly increased abundances of Cladosporium, Alternaria, and Aspergillus, which led to higher fungal diversity than pretreatment samples. The bacterial profiles after treatment and 1 week post-treatment revealed significantly decreased abundances of Brevibacterium, Finegoldia, and Facklamia. The abundance of Streptococcus and bacterial diversity were also significantly decreased at 1 week post-treatment. The disease severity was positively associated with the abundance of Trichophyton, Arthroderma, Finegoldia, Facklamia, Brevibacterium, Corynebacterium, and Porphyromonas.
The clioquinol 3% cream was efficient on treating interdigital tinea pedis by decreasing the abundance of pathogenic fungus, recovering the normal balance of the fungal and bacterial communities, and restore species diversity.
指间足癣是足癣的一种常见类型，发生在脚趾间，且容易复发。最近，指间足癣的皮肤微生物群分析显示，除真菌感染外，细菌微生物群也发生了变化。
研究3%氯碘羟喹乳膏治疗指间足癣的疗效和安全性，并描述治疗期间皮肤微生物群的变化。
在一项纵向前瞻性研究中，对指间足癣患者的临床特征和皮肤微生物群进行了调查。总共招募了28名参与者，每天两次将3%氯碘羟喹乳膏局部涂抹于目标皮肤病变处，持续1周。在基线、治疗后和治疗后1周进行疾病严重程度评估、真菌显微镜检查以及用于皮肤微生物群分析的样本采集。
与基线相比，患者的疾病严重程度、皮损评分、瘙痒评分和异味评分在治疗后和治疗后1周时显著降低（P < 0.05）。治疗后和治疗后1周时的真菌谱显示，毛癣菌的丰度显著降低，枝孢菌、链格孢菌和曲霉的丰度显著增加，这导致真菌多样性高于治疗前样本。治疗后和治疗后1周时的细菌谱显示，短杆菌属、菲氏菌属和法克勒菌属的丰度显著降低。治疗后1周时，链球菌的丰度和细菌多样性也显著降低。疾病严重程度与毛癣菌、节皮菌属、菲氏菌属、法克勒菌属、短杆菌属、棒状杆菌属和卟啉单胞菌属的丰度呈正相关。
3%氯碘羟喹乳膏通过降低致病真菌的丰度、恢复真菌和细菌群落的正常平衡以及恢复物种多样性，对治疗指间足癣有效。
