血清沉默调节蛋白-1浓度在代谢功能障碍相关脂肪性肝病诊断中的临床价值

The clinical value of serum sirtuin-1 concentration in the diagnosis of metabolic dysfunction-associated steatotic liver disease.

作者信息

Amirkhizi Farshad, Taghizadeh Mahdiyeh, Khalese-Ranjbar Banafshe, Hamedi-Shahraki Soudabeh, Asghari Somayyeh

机构信息

Department of Nutrition, School of Public Health, Zabol University of Medical Sciences, Zabol, Iran.

Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, No#44, Hojjatdoust St., Naderi St., Keshavarz Blvd, Tehran, 141556117, Iran.

出版信息

BMC Gastroenterol. 2025 Jan 22;25(1):27. doi: 10.1186/s12876-025-03613-8.

DOI:10.1186/s12876-025-03613-8

PMID:39844087

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11753077/

Abstract

BACKGROUND

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease and can affect individuals without producing any symptoms. We aimed to explore the value of serum sirtuin-1 (Sirt-1) in the diagnosis of MASLD.

METHODS

This case-control study analyzed data collected from 190 individuals aged 20 to 60 years. Anthropometric parameters, demographic information, and serum biochemical variables-including glycemic parameters, lipid profiles, liver enzymes, and Sirt-1 levels-were assessed. The correlation between serum Sirt-1 and biochemical variables was examined using Pearson's correlation coefficient. Receiver operating characteristic (ROC) curve analysis was employed to evaluate the diagnostic value of serum Sirt-1 in the context of MASLD.

RESULTS

Serum Sirt-1 levels was significantly lower in the MASLD group (p < 0.001) and was inversely correlated with serum insulin (r = -0.163, p = 0.025), HOMA-IR (r = -0.169, p = 0.020) and triglyceride (r = -0.190, p = 0.009) and positively correlated with serum levels of high-density lipoprotein cholesterol (HDL-C) (r = 0.214, p = 0.003). The area under the curve (AUC) of Sirt-1 to predict the presence of MASLD was 0.76 (p < 0.001, 95% CI: 0.69, 0.82) with a sensitivity of 78.9, specificity of 61.1, positive predictive value (PPV) of 67.0%, and negative predictive value (NPV) of 74.0%. The optimal cutoff, determined using Youden's index, was 23.75 ng/mL. This indicates that serum Sirt-1 levels below 23.75 ng/mL may be indicative of MASLD.

CONCLUSIONS

The present study demonstrated that serum Sirt-1 levels were significantly lower in patients with MASLD. Furthermore, these levels were correlated with various metabolic parameters, including insulin resistance and the serum lipid profile. A serum Sirt-1 level below the cutoff of 23.75 ng/mL exhibited a significant association with the presence of MASLD, suggesting its potential utility in identifying patients with this condition.

摘要

背景

代谢功能障碍相关脂肪性肝病（MASLD）是最常见的慢性肝病，可在无任何症状的情况下影响个体。我们旨在探讨血清沉默调节蛋白-1（Sirt-1）在MASLD诊断中的价值。

方法

本病例对照研究分析了从190名年龄在20至60岁的个体收集的数据。评估了人体测量参数、人口统计学信息和血清生化变量，包括血糖参数、血脂谱、肝酶和Sirt-1水平。使用Pearson相关系数检验血清Sirt-1与生化变量之间的相关性。采用受试者工作特征（ROC）曲线分析来评估血清Sirt-1在MASLD背景下的诊断价值。

结果

MASLD组血清Sirt-1水平显著降低（p < 0.001），且与血清胰岛素（r = -0.163，p = 0.025）、稳态模型评估的胰岛素抵抗（HOMA-IR）（r = -0.169，p = 0.020）和甘油三酯（r = -0.190，p = 0.009）呈负相关，与血清高密度脂蛋白胆固醇（HDL-C）水平呈正相关（r = 0.214，p = 0.003）。Sirt-1预测MASLD存在的曲线下面积（AUC）为0.76（p < 0.001，95%可信区间：0.69，0.82），敏感性为78.9%，特异性为61.1%，阳性预测值（PPV）为67.0%，阴性预测值（NPV）为74.0%。使用约登指数确定的最佳截断值为23.75 ng/mL。这表明血清Sirt-1水平低于23.75 ng/mL可能提示MASLD。