伊朗儿童和成人非酒精性脂肪性肝病的患病率：一项系统评价和荟萃分析
The Prevalence of Non-Alcoholic Fatty Liver Disease in Iranian Children and Adult Population: A Systematic Review and Meta-Analysis.
作者信息
Hassanipour Soheil, Amini-Salehi Ehsan, Joukar Farahnaz, Khosousi Mohammad-Javad, Pourtaghi Farideh, Ansar Malek Moein, Mahdavi-Roshan Marjan, Heidarzad Forough, Rashidi-Mojdehi Golnaz, Abdzadeh Elham, Vakilpour Azin, Mansour-Ghanaei Fariborz
机构信息
Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
出版信息
Iran J Public Health. 2023 Aug;52(8):1600-1612. doi: 10.18502/ijph.v52i8.13399.
BACKGROUND
Non-alcoholic fatty liver disease (NAFLD) is the world's most common etiology of chronic liver disease. In this systematic review and meta-analysis, we estimated the prevalence of NAFLD in the Iranian children and adult population.
METHODS
A comprehensive search of five international databases, including PubMed, ISI/WOS, ProQuest, Scopus, and Google Scholar, was done from inception to Nov 2022. Studies on NAFLD patients and their risk factors were selected for meta-analysis. The quality of the included studies was assessed by The Joanna Briggs Institute (JBI) Critical Appraisal Checklist for cross-sectional, and cohort studies. The heterogeneity between studies was investigated using Cochran test and I2 statistics. Random and fixed effect models were used for heterogenic and non-heterogenic studies, respectively. We used Comprehensive Meta-Analysis version 3 for conducting meta-analysis.
RESULTS
Twenty studies were finally included. The total prevalence of NAFLD in children, boys, and girls was 6.7% (95% CI: 0.02-0.18), 12.5% (95% CI: 0.04-0.29) and, 10.1% (95% CI: 0.04-0.21), respectively. The total prevalence of NAFLD in obese children, obese boys, and obese girls was 42% (95% CI: 0.18-0.69), 44% (95% CI: 0.13-0.80), and 33 % (95% CI: 0.13-0.62), respectively. The total prevalence of NAFLD in adults was 36.9% (95% CI: 0.31-0.42). The prevalence of NAFLD in men and women was 33.8% (95% CI: 0.27-0.41) and 29.9% (95% CI: 0.21-0.40), respectively.
CONCLUSION
NAFLD prevalence in Iranian adults and obese children is considerable; however, data about the children population was insufficient.
背景
非酒精性脂肪性肝病（NAFLD）是全球最常见的慢性肝病病因。在本系统评价和荟萃分析中，我们估计了伊朗儿童和成人中NAFLD的患病率。
方法
对包括PubMed、ISI/WOS、ProQuest、Scopus和谷歌学术在内的五个国际数据库进行了全面检索，检索时间从建库至2022年11月。选择关于NAFLD患者及其危险因素的研究进行荟萃分析。纳入研究的质量通过乔安娜·布里格斯研究所（JBI）横断面研究和队列研究的批判性评价清单进行评估。使用 Cochr an检验和I2统计量研究研究之间的异质性。随机效应模型和固定效应模型分别用于异质性和非异质性研究。我们使用综合荟萃分析第3版进行荟萃分析。
结果
最终纳入20项研究。儿童、男孩和女孩中NAFLD的总患病率分别为6.7%（95%CI：0.02 - 0.18）、12.5%（95%CI：0.04 - 0.29）和10.1%（95%CI：0.04 - 0.21）。肥胖儿童、肥胖男孩和肥胖女孩中NAFLD的总患病率分别为42%（95%CI：0.18 - 0.69）、44%（95%CI：0.13 - 0.80）和33%（95%CI：0.13 - 0.62）。成人中NAFLD的总患病率为36.9%（95%CI：0.31 - 0.42）。男性和女性中NAFLD的患病率分别为33.8%（95%CI：0.27 - 0.41）和29.9%（95%CI：0.21 - 0.40）。
结论
伊朗成人和肥胖儿童中NAFLD的患病率相当高；然而，关于儿童人群的数据不足。
Zotero 插件