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[红外线和紫外线A对人体皮肤的影响及其在特应性皮炎治疗中的疗效]

[Effects of infrared and UVA rays on the human skin and their efficacy in the treatment of atopic dermatitis].

作者信息

Pullmann H, Möres E, Reinbach S

出版信息

Z Hautkr. 1985 Jan;60(1-2):171-7.

PMID:3984429
Abstract

Radiation with ultrared light (UR) and with a supposed pure UVA high pressure tube leads to increase of the skin surface temperature, which is linear during UR radiation and causes pain at 42 degrees C. During UVA radiation, the skin surface temperature increases in a parabolic curve and approximates 42.3 degrees C asymptotically. There is no pain. Following both UR and UVA, erythema occurs at 41.4 degrees C. UVA additionally results in immediate pigmentation dependent on the dose between 6 and 20 J/cm2. UR does not induce any pigmentation. The erythema induced by UR disappears completely within 6 hours. Corresponding to the dose, the erythema persists up to 7 days after UV radiation. Immediate and delayed erythema obviously overlap. The pigmentation shows a biphasic reaction. There is a maximum immediately at the end of UV radiation, reduction between 6 and 24 hours after radiation. The course of erythema and pigmentation indicates a clinically relevant part of UVB in the emission spectrum supposed to be pure UVA. A therapeutical trial was performed in 40 patients suffering from severe atopic dermatitis. In a group of 10 patients, daily UR radiation up to beginning pain showed good results within 3 weeks. The therapeutic effects were even better in another group of patients radiated with suberythematous doses of UVA daily for the same time. UVA radiations twice a week for 6 to 8 weeks were less effective.

摘要

用红外光(UR)以及假定的纯UVA高压灯管进行辐射会导致皮肤表面温度升高,在UR辐射期间呈线性升高,并在42摄氏度时引起疼痛。在UVA辐射期间,皮肤表面温度呈抛物线形升高,并渐近地接近42.3摄氏度。没有疼痛。在UR和UVA辐射后,在41.4摄氏度时都会出现红斑。UVA还会导致即时色素沉着,其程度取决于6至20 J/cm²之间的剂量。UR不会诱导任何色素沉着。UR诱导的红斑在6小时内完全消失。对应于剂量,红斑在紫外线辐射后可持续长达7天。即时红斑和延迟红斑明显重叠。色素沉着表现为双相反应。在紫外线辐射结束时立即出现最大值,在辐射后6至24小时之间减少。红斑和色素沉着的过程表明,在假定为纯UVA的发射光谱中,UVB存在临床相关部分。对40名患有重度特应性皮炎的患者进行了一项治疗试验。在一组10名患者中,每天进行UR辐射直至开始疼痛,在3周内显示出良好的效果。在另一组患者中,每天用亚红斑剂量的UVA进行相同时间的辐射,治疗效果更好。每周进行两次UVA辐射,持续6至8周,效果较差。

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