严重精神障碍中免疫标志物水平失调与端粒长度之间关联的证据有限。
Limited evidence of association between dysregulated immune marker levels and telomere length in severe mental disorders.
作者信息
Ormerod Monica B E G, Ueland Thor, Aas Monica, Hjell Gabriela, Rødevand Linn, Sæther Linn Sofie, Lunding Synve Hoffart, Johansen Ingrid Torp, Mlakar Vid, Andreou Dimitrios, Ueland Torill, Lagerberg Trine V, Melle Ingrid, Djurovic Srdjan, Andreassen Ole A, Steen Nils Eiel
机构信息
Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
出版信息
Acta Neuropsychiatr. 2025 Jan 23;37:e4. doi: 10.1017/neu.2024.62.
OBJECTIVE
Accelerated ageing indexed by telomere attrition is suggested in schizophrenia spectrum- (SCZ) and bipolar disorders (BD). While inflammation may promote telomere shortening, few studies have investigated the association between telomere length (TL) and markers of immune activation and inflammation in severe mental disorders.
METHODS
Leucocyte TL defined as telomere template/amount of single-copy gene template (T/S ratio), was determined in participants with SCZ ( = 301) or BD ( = 211) and a healthy control group (HC, = 378). TL was analysed with linear regressions for associations with levels of 12 immune markers linked to SCZ or BD. Adjustments were made for a broad range of potential confounding variables. TL was measured by quantitative polymerase chain reaction (qPCR) and the immune markers were measured by enzyme immunoassays.
RESULTS
A positive association between levels of soluble tumour necrosis factor receptor 1A (sTNF-R1) and TL in SCZ ( = 0.191, = 0.012) was observed. Plasma levels of the other immune markers were not significantly associated with TL in the BD, SCZ or HC groups.
CONCLUSION
There was limited evidence of association between immune markers and TL in SCZ and BD. The results provide little support for involvement of immune dysregulation, as reflected by current systemic markers, in telomere attrition-related accelerated ageing in severe mental disorders.
目的
精神分裂症谱系障碍（SCZ）和双相情感障碍（BD）中存在以端粒损耗为指标的加速衰老现象。虽然炎症可能促进端粒缩短，但很少有研究调查严重精神障碍中端粒长度（TL）与免疫激活和炎症标志物之间的关联。
方法
在SCZ患者（n = 301）、BD患者（n = 211）和健康对照组（HC，n = 378）中测定白细胞TL，定义为端粒模板/单拷贝基因模板量（T/S比值）。用线性回归分析TL与12种与SCZ或BD相关的免疫标志物水平之间的关联。对一系列潜在的混杂变量进行了调整。TL通过定量聚合酶链反应（qPCR）测量，免疫标志物通过酶免疫测定法测量。
结果
观察到SCZ患者中可溶性肿瘤坏死因子受体1A（sTNF-R1）水平与TL呈正相关（r = 0.191，P = 0.012）。在BD、SCZ或HC组中，其他免疫标志物的血浆水平与TL无显著关联。
结论
在SCZ和BD中，免疫标志物与TL之间的关联证据有限。目前全身标志物所反映的免疫失调参与严重精神障碍中端粒损耗相关的加速衰老，这一结果几乎没有提供支持。
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