逆势而行：黎巴嫩一例成功治愈的丑角鱼鳞病病例。
Defying the Odds: A Case of Successfully Treated Harlequin Ichthyosis in Lebanon.
作者信息
Hamam Bassel, Saleh Sarah, Yaacoub Miled, Chebbo Houssein, Jalloul Sarah, Karam Karam, Houmani Rima
机构信息
Department of Radiology University of Balamand Balamand Lebanon.
Faculty of Medicine University of Balamand Balamand Lebanon.
出版信息
Clin Case Rep. 2025 Jan 22;13(1):e70111. doi: 10.1002/ccr3.70111. eCollection 2025 Jan.
Harlequin ichthyosis is a rare skin disorder affecting newborns characterized by a scaly skin, flexed limbs, ectropium, and eclabium. The overall incidence of HI is 1 in 300,000 births, with approximately only 200 cases reported worldwide. Some studies uncovered a TH17 immune skewing in patients with HI, which is also seen in psoriasis. We herein present a case of a newborn found to have harlequin ichthyosis, whom his mother is known to have psoriasis. The baby was treated with topical antibiotics and retinoid creams. The baby then exhibited smoother skin with less scaling and flatter fissures.
丑角鱼鳞病是一种罕见的影响新生儿的皮肤疾病，其特征为皮肤鳞屑、肢体弯曲、睑外翻和唇外翻。丑角鱼鳞病的总体发病率为每30万例出生中有1例，全球报告的病例约仅200例。一些研究发现丑角鱼鳞病患者存在TH17免疫失衡，银屑病患者中也可见这种情况。我们在此报告一例新生儿被发现患有丑角鱼鳞病，其母亲患有银屑病。该婴儿接受了外用抗生素和维甲酸乳膏治疗。随后婴儿的皮肤变得更光滑，鳞屑减少，裂隙变平。
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