Dwyer Zachary A, Shields Tanner, Parks Jackson, Byler Benjamin, Hilton Baydon E, Houser Jeremy J
Department of Anatomy, A.T. Still University of Health Sciences - Kirksville College of Osteopathic Medicine, Kirksville, USA.
Department of Dermatology, Northeast Regional Medical Center, Kirksville, USA.
Cureus. 2024 Dec 23;16(12):e76268. doi: 10.7759/cureus.76268. eCollection 2024 Dec.
Erythema multiforme major (EMM) is an acute, immune-mediated mucocutaneous disease that rarely affects the genital mucosal surfaces. This study describes a 39-year-old male with this rare disease and unusual presentation. The patient presented to an emergency department with oral lesions, drainage from both eyes, injected sclera, and characteristic targetoid lesions on the face, upper extremities, torso, and plantar surfaces of the feet. Laboratory results indicated a latent herpes simplex virus type 1 (HSV-1) infection and an active infection. The patient later developed dysuria and sloughing of the urethral mucosa, which was managed conservatively with topical lidocaine and petroleum-impregnated gauze. This treatment resulted in full healing and return of function. Currently, there is limited guidance on treating genital manifestations of EMM. Although this disease is rare, protocols should be developed for the treatment and care of future patients.
重症多形红斑（EMM）是一种急性免疫介导的黏膜皮肤疾病，很少累及生殖器黏膜表面。本研究描述了一名患有这种罕见疾病且表现异常的39岁男性。该患者因口腔病变、双眼分泌物、巩膜充血以及面部、上肢、躯干和足底出现特征性靶形皮损而就诊于急诊科。实验室检查结果显示存在潜伏性1型单纯疱疹病毒（HSV-1）感染和活动性感染。患者随后出现排尿困难和尿道黏膜脱落，采用局部利多卡因和浸有凡士林的纱布进行保守治疗。该治疗使病情完全愈合且功能恢复。目前，关于EMM生殖器表现的治疗指导有限。尽管这种疾病罕见，但应为未来患者制定治疗和护理方案。
