Zhou Yi, Teng Wen, Luo Liang, Zhou Ping, Fan Guidi, Liu Haiying
Wuxi School of Medicine, Jiangnan University, Wuxi, China.
Department of Intensive Care Unit, Wuxi No.2 People's Hospital (Jiangnan University Medical Center), Wuxi, China.
Front Psychiatry. 2025 Jan 8;15:1505518. doi: 10.3389/fpsyt.2024.1505518. eCollection 2024.
In this study, we examine the network structure of posttraumatic stress disorder (PTSD), including core symptoms and strong edges in patients undergoing chemotherapy for colorectal cancer in China, and lay the groundwork for targeted psychological interventions for these patients.
This study included 360 colorectal cancer patients receiving chemotherapy at a third-class hospital in Wuxi, China, from November 2023 to June 2024. The severity of each item of PTSD was assessed using the DSM-5 Checklist (PCL-5). A network analysis approach was conducted in R to pinpoint core symptoms and investigate notable edge connections within the network.
The accuracy and stability of the PTSD network structure model were relatively good, and the results indicated that robust connections emerged between avoidance of thoughts and avoidance of reminders, hypervigilance and exaggerated startle response, and loss of interest and detachment. The most central node was emotional cue reactivity, which was more closely connected with other symptoms, while self-destructive/reckless behavior was the lowest central node.
Emotional cue reactivity was proved to be the most prominent symptom in the PTSD symptom network in colorectal cancer patients treated with chemotherapy, and targeting it in interventions could lead to substantial improvements.
在本研究中，我们探究了中国接受结直肠癌化疗患者的创伤后应激障碍（PTSD）的网络结构，包括核心症状和强关联，为这些患者的针对性心理干预奠定基础。
本研究纳入了2023年11月至2024年6月在中国无锡一家三级医院接受化疗的360例结直肠癌患者。使用《精神疾病诊断与统计手册》第5版检查表（PCL-5）评估PTSD各项目的严重程度。在R语言中采用网络分析方法来确定核心症状并研究网络内显著的关联。
PTSD网络结构模型的准确性和稳定性相对较好，结果表明在回避想法与回避提示物、过度警觉与夸张的惊跳反应以及兴趣丧失与情感疏离之间出现了强关联。最核心的节点是情绪线索反应性，它与其他症状联系更为紧密，而自我毁灭/鲁莽行为是中心性最低的节点。
事实证明，情绪线索反应性是接受化疗的结直肠癌患者PTSD症状网络中最突出的症状，针对该症状进行干预可能会带来实质性改善。
