Han Yuping, Yao Yue, Wen Xinyi, Wang Hao, Li Shurong, Su Bingyin
Development and Regeneration Key Lab of Sichuan Province, Department of Histology and Embryology, Department of Pathology, Chengdu Medical College, Chengdu, China.
Front Bioeng Biotechnol. 2025 Jan 8;12:1480573. doi: 10.3389/fbioe.2024.1480573. eCollection 2024.
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the gradual loss of dopaminergic neurons in the substantia nigra and the accumulation of α-synuclein aggregates known as Lewy bodies. MicroRNA-7 (miR-7) targets the gene , which encodes α-synuclein, reducing its expression and alleviating neuronal damage in PD. Regulating the post-transcriptional levels of α-synuclein through miR-7 effectively inhibits its production. Herein, we use nanodiamonds as carriers to deliver miR-7 (N-7), which can effectively protect dopaminergic neurons. Dopaminergic neurons efficiently take up N-7 and express miR-7. N-7 inhibits the expression of α-synuclein, reduces oxidative stress and restores dopamine levels effectively. These findings suggest that nanocomposites have significant potential in treating PD.
帕金森病（PD）是一种神经退行性疾病，其特征是黑质中多巴胺能神经元逐渐丧失，以及被称为路易小体的α-突触核蛋白聚集体的积累。微小RNA-7（miR-7）靶向编码α-突触核蛋白的基因，降低其表达并减轻帕金森病中的神经元损伤。通过miR-7调节α-突触核蛋白的转录后水平可有效抑制其产生。在此，我们使用纳米金刚石作为载体来递送miR-7（N-7），其可有效保护多巴胺能神经元。多巴胺能神经元有效摄取N-7并表达miR-7。N-7抑制α-突触核蛋白的表达，降低氧化应激并有效恢复多巴胺水平。这些发现表明纳米复合材料在治疗帕金森病方面具有巨大潜力。
