[Therapeutic effect of cavinton in chronic cerebral circulatory insufficiency].

Eighty-one patients with chronic forms of cerebral ischemia were treated with cavinton administered by two combined routes (parenteral and oral). The treatment brought about a rapid and significant regression of the subjective manifestations of the disease, particularly of emotionally-volitional and asthenic disturbances. REG findings show that the drug improved the cerebral blood supply through increasing the volume of the fraction of the cardiac output which reached the brain and a simultaneous decrease in the peripheral resistance of the cerebral vessels. The beneficial properties of the drug include a prolonged therapeutic effect (from 40 min to 6 hours with intravenous infusion), the absence of the intracerebral steal syndrome, a mild effect on the central hemodynamics allowing its administration in increasing doses even in elderly and old patients.