注射用和口服艾滋病病毒暴露前预防药物在注射毒品的男性和女性中用于预防艾滋病的相关研究兴趣。
Interest in Injectable and Oral PrEP for HIV Prevention Among Women and Men Who Inject Drugs.
作者信息
Bhatraju Elenore P, Tsui Judith I, Heo Moonseong, Sivaraj Laksika B, Lopes Snehal S, Mehta Shruti, Lum Paula, Taylor Lynn E, Feinberg Judith, Kim Arthur, Norton Brianna, Pericot-Valverde Irene, Page Kimberly A, Litwin Alain H
机构信息
Division of General Internal Medicine, Department of Medicine, University of Washington, Seattle, WA (EPB, JIT); Department of Public Health Sciences, Clemson University, Clemson, SC (MH, SSL); School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada (LBS); Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD (SM); Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA (PL); Department of Pharmacy Practice and Clinical Research, University of Rhode Island, Kingston, RI (LET); West Virginia University School of Medicine, Morgantown, WV (JF); Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA (AK); Department of Medicine, Albert Einstein College of Medicine/Montefiore Medical Center, New York, NY (BN); Department of Psychology, Clemson University, Clemson, SC (IP-V); University of New Mexico Health Sciences Center, Department of Internal Medicine, University of New Mexico, Albuquerque, NM (KP); and Department of Medicine, University of South Carolina School of Medicine, Greenville, SC (AHL).
出版信息
J Addict Med. 2025;19(4):479-483. doi: 10.1097/ADM.0000000000001440. Epub 2025 Feb 3.
BACKGROUND
People who inject drugs (PWID) are at increased risk for human immunodeficiency virus (HIV). Women who inject are a particularly vulnerable group. Preexposure prophylaxis (PrEP) is effective, but access and uptake has been limited. This study evaluated interest and concerns around oral and injectable PrEP among PWID based on gender.
METHODS
This cross-sectional analysis of survey data from 8 sites in the United States (n = 284) assessed attitudes and interest in PrEP. Demographics, HIV risk behaviors, and attitudes toward PrEP were described overall and by self-identified gender (female vs male).
RESULTS
Participants completed the PrEP survey between 2019 and 2021. The mean (standard deviation) age was 44.6 (11.4) years, 29% female, and 66% White. Mean self-perceived HIV risk score (0-10) was 2.3 (standard deviation 2.0). Interest in injectable PrEP (49.5%) was significantly higher than interest in daily oral PrEP (20.1%) ( P ≤ 0.001). The most cited concerns were medication side effects (53%) and medication interactions (39.2%). Perceived HIV risk and PrEP concerns were not significantly different between genders.
CONCLUSIONS
There was high interest in injectable PrEP, particularly among females. The top concerns were medication side effects and medication interactions. These results suggest high acceptability of injectable PrEP among PWID. Future research could explore the advantages identified by female participants as well as implementation strategies for access and uptake among this vulnerable population.
背景
注射吸毒者感染人类免疫缺陷病毒（HIV）的风险增加。注射毒品的女性是特别脆弱的群体。暴露前预防（PrEP）是有效的，但可及性和接受程度有限。本研究根据性别评估了注射吸毒者对口服和注射用PrEP的兴趣及担忧。
方法
对来自美国8个地点的调查数据（n = 284）进行横断面分析，评估对PrEP的态度和兴趣。总体上以及按自我认定的性别（女性与男性）描述人口统计学、HIV风险行为和对PrEP的态度。
结果
参与者在2019年至2021年期间完成了PrEP调查。平均（标准差）年龄为44.6（11.4）岁，29%为女性，66%为白人。自我感知的HIV风险平均评分为（0 - 10）2.3（标准差2.0）。对注射用PrEP的兴趣（49.5%）显著高于每日口服PrEP的兴趣（20.1%）（P≤0.001）。最常提及的担忧是药物副作用（53%）和药物相互作用（39.2%）。不同性别之间感知到的HIV风险和对PrEP的担忧没有显著差异。
结论
对注射用PrEP有很高的兴趣，尤其是在女性中。最主要的担忧是药物副作用和药物相互作用。这些结果表明注射用PrEP在注射吸毒者中具有很高的可接受性。未来的研究可以探索女性参与者所确定的优势以及针对这一脆弱人群的可及性和接受程度的实施策略。
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