Chaturvedi Shivani, Paul Amisha, Singh Samya, Akduman Levent, Saxena Sandeep
Department of Ophthalmology, King George's Medical University, Lucknow 226003, India.
EyeCare Partners, St. Louis, MO 63117, USA.
Vision (Basel). 2025 Jan 13;9(1):4. doi: 10.3390/vision9010004.
The goal was to study the ellipsoid zone (EZ) as a structural biomarker for final visual outcomes after pharmacological intervention in center-involving diabetic macular edema (DME) and surgical intervention for full-thickness macular holes (FTMHs).
This was a tertiary care center-based retrospective study. After sample size calculations, data from 64 consecutive cases were collected, with subjects aged between 40 and 60 years. Thirty-two cases of DME with anti-vascular endothelial growth factor (VEGF) therapy and 32 cases of FTMHs with successful macular hole surgery (MHS) were studied. Spectral-domain optical coherence tomography (SD-OCT) data were collected. Measurements of EZ defects documented at the time of presentation and 12 weeks after intervention were analyzed using the caliper function of the machine. EZ restoration was graded, and a Pearson correlation analysis was performed.
Mean logMAR VA decreased after intravitreal therapy (IVT) from 1.12 ± 0.22 pre-intervention to 0.81 ± 0.41 post-intervention and after MHS, from 1.05 + 0.25 to 0.62 + 0.11 ( < 0.001). EZ disruption reduced from 73.4% to 19.4% after IVT and from 67% to 19.3% after MHS. DME and MHS postoperative visual acuity and residual EZ defect were observed to have a statistically significant linear correlation (r = 0.794, < 0.001 and r = 0.894, < 0.001, respectively). The EZ was found to be an excellent structural biomarker for final BCVA (area under curve = 0.95 for DME and 1.00 for MHS).
Notable EZ restoration results were obtained from pharmacological and surgical interventions. The EZ proves to be a critical structural biomarker for predicting visual outcomes in center-involving DME and MHS.
本研究旨在探讨椭圆体带（EZ）作为累及黄斑中心凹的糖尿病性黄斑水肿（DME）药物干预及全层黄斑裂孔（FTMH）手术干预后最终视力预后的结构生物标志物。
这是一项基于三级医疗中心的回顾性研究。在完成样本量计算后，收集了64例年龄在40至60岁之间的连续病例数据。研究了32例接受抗血管内皮生长因子（VEGF）治疗的DME患者和32例黄斑裂孔手术（MHS）成功的FTMH患者。收集了频域光学相干断层扫描（SD-OCT）数据。使用仪器的卡尺功能分析了就诊时和干预后12周记录的EZ缺陷测量值。对EZ恢复情况进行分级，并进行Pearson相关性分析。
玻璃体腔内治疗（IVT）后平均logMAR视力从干预前的1.12±0.22降至干预后的0.81±0.41，MHS后从1.05 + 0.25降至0.62 + 0.11（P<0.001）。IVT后EZ破坏率从73.4%降至19.4%，MHS后从67%降至19.3%。观察到DME和MHS术后视力与残余EZ缺陷具有统计学显著的线性相关性（分别为r = 0.794，P<0.001和r = 0.894，P<0.001）。发现EZ是最终最佳矫正视力（BCVA）的优秀结构生物标志物（DME的曲线下面积=0.95，MHS的曲线下面积=1.00）。
药物和手术干预均取得了显著的EZ恢复结果。EZ被证明是预测累及黄斑中心凹的DME和MHS视力预后的关键结构生物标志物。
