Sharma Garima, Akhtar Juber, Khan Mohammad Irfan, Ahmad Mohammad, Sharma Prakash Kumar
Faculty of Pharmacy, Integral University, Kursi Road, Lucknow, U.P., 226026, India.
Department of Anesthesiology, Hind Institute of Medical Sciences, Safedabad, Lucknow, U.P., 225001, India.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Jan 23. doi: 10.1007/s00210-024-03752-x.
A volatile organic substance produced from jasmonic acid, methyl jasmonate (MJ/MeJA), is an important plant hormone involved in stress responses and plant defense. Apart from its role in plants, MJ has garnered significant attention because of its pharmacological effects and possible therapeutic use in human health. This thorough analysis looks into the many biological actions of MJ, such as its antioxidant, anti-inflammatory, and anti-cancer effects. The underlying mechanism of these actions is examined, emphasizing MJ's ability to modulate important signaling pathways, cause cancer cells to undergo apoptosis, and boost immunological responses. Furthermore, MJ's capacity to manage long-term illnesses like cancer and neurological conditions like Parkinson's and Alzheimer's is examined. Preclinical and clinical research are beginning to provide evidence that MJ may be a useful medicinal drug. Nevertheless, more research is needed to fully understand its mode of action, enhance its administration methods, and evaluate its efficacy and safety in humans. This review highlights MJ's therapeutic promise and supports earlier research into its pharmacological capabilities and possible medical applications. This abstract highlights methyl jasmonate's pharmacological effects and therapeutic potential by providing a concise overview of the main topics covered in a thorough review.
茉莉酸甲酯（MJ/MeJA）是一种由茉莉酸产生的挥发性有机物质，是一种参与应激反应和植物防御的重要植物激素。除了在植物中的作用外，MJ因其药理作用以及在人类健康方面可能的治疗用途而备受关注。这项全面分析研究了MJ的多种生物学作用，如抗氧化、抗炎和抗癌作用。研究了这些作用的潜在机制，强调了MJ调节重要信号通路、使癌细胞发生凋亡以及增强免疫反应的能力。此外，还研究了MJ对癌症等长期疾病以及帕金森氏症和阿尔茨海默氏症等神经疾病的控制能力。临床前和临床研究开始提供证据表明MJ可能是一种有用的药物。然而，需要更多研究来充分了解其作用方式、改进其给药方法，并评估其在人体中的疗效和安全性。本综述强调了MJ的治疗前景，并支持对其药理能力和可能的医学应用的早期研究。本摘要通过简要概述一篇全面综述中涵盖的主要主题，突出了茉莉酸甲酯的药理作用和治疗潜力。
