He Liujun, Moon Jaeyoung, Cai Chenghui, Hao Yalan, Lee Hyorin, Kim Wootae, Zhao Fei, Lou Zhenkun
College of Biology, Hunan University, Changsha 410082, China.
Department of Integrated Biomedical Science, Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Cheonan, Chungcheongnam-do 31151, Republic of Korea.
DNA Repair (Amst). 2025 Feb;146:103811. doi: 10.1016/j.dnarep.2025.103811. Epub 2025 Jan 15.
Proper chromatin remodeling is crucial for many cellular physiological processes, including the repair of DNA double-strand break (DSB). While the mechanism of DSB repair is well understood, the connection between chromatin remodeling and DSB repair remains incompletely elucidated. In this review, we aim to highlight recent studies demonstrating the close relationship between chromatin remodeling and DSB repair. We summarize the impact of DSB repair on chromatin, including nucleosome arrangement, chromatin organization, and dynamics, and conversely, the role of chromatin architecture in regulating DSB repair. Additionally, we also summarize the contribution of chromatin remodeling complexes to cancer biology through DNA repair and discuss their potential as therapeutic targets for cancer.
适当的染色质重塑对于许多细胞生理过程至关重要，包括DNA双链断裂（DSB）的修复。虽然DSB修复的机制已得到充分了解，但染色质重塑与DSB修复之间的联系仍未完全阐明。在本综述中，我们旨在强调最近的研究，这些研究证明了染色质重塑与DSB修复之间的密切关系。我们总结了DSB修复对染色质的影响，包括核小体排列、染色质组织和动力学，反之，染色质结构在调节DSB修复中的作用。此外，我们还总结了染色质重塑复合物通过DNA修复对癌症生物学的贡献，并讨论了它们作为癌症治疗靶点的潜力。
