Ostrower V G
Postgrad Med J. 1979;55 Suppl 4:82-4.
Fifty-four children with acute diarrhoea were treated orally with 50 mg/kg/day of either ampicillin in 4 divided doses, or with cefaclor in 3 divided doses for 5 days. Shigella was isolated from the stool of 28 patients, 6 of whom were hospitalized. All isolates, including ampicillin-resistant strains, were susceptible in vitro to cefaclor. For ampicillin-sensitive infections, the clinical response and clearing of Shigella from stools appeared to occur more rapidly in patients treated with ampicillin than in those treated with cefaclor. In areas where ampicillin resistance is a problem, cefaclor appears not to be a drug of choice for the treatment of Shigella.
54名急性腹泻儿童接受了口服治疗，其中一组每天按每千克体重50毫克的剂量服用氨苄西林，分4次给药；另一组按每千克体重50毫克的剂量服用头孢克洛，分3次给药，疗程均为5天。从28名患者的粪便中分离出志贺菌，其中6名患者住院治疗。所有分离菌株，包括耐氨苄西林菌株，在体外对头孢克洛均敏感。对于对氨苄西林敏感的感染，接受氨苄西林治疗的患者临床反应以及粪便中志贺菌清除的速度似乎比接受头孢克洛治疗的患者更快。在氨苄西林耐药成问题的地区，头孢克洛似乎不是治疗志贺菌的首选药物。
