Kittipibul Veraprapas, Lam Carolyn S P
Duke Clinical Research Institute, Durham, NC, USA.
Division of Cardiology, Duke University School of Medicine, Durham, NC, USA.
Heart Fail Rev. 2025 Jan 24. doi: 10.1007/s10741-025-10488-0.
Heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) are increasingly prevalent cardiovascular conditions, particularly among the elderly population. These two conditions share common risk factors and often coexist, leading to a complex interplay that alters the clinical course of each other. The pathophysiology of HFpEF is multifaceted and intricately linked, with atrial disease serving as a common pathophysiological pathway. Diagnosis of HFpEF in the setting of AF, and vice versa, can be challenging; thus, effective screening and diagnostic strategies are needed. Understanding the complex relationship between HFpEF and AF is crucial for optimal patient management by timely disease recognition and identification of therapeutic interventions or treatment strategies.
射血分数保留的心力衰竭（HFpEF）和心房颤动（AF）是日益普遍的心血管疾病，在老年人群中尤为常见。这两种疾病有共同的危险因素，且常同时存在，导致复杂的相互作用，改变彼此的临床病程。HFpEF的病理生理学是多方面且错综复杂地相互关联的，心房疾病是常见的病理生理途径。在AF背景下诊断HFpEF，反之亦然，可能具有挑战性；因此，需要有效的筛查和诊断策略。了解HFpEF和AF之间的复杂关系对于通过及时识别疾病和确定治疗干预措施或治疗策略来实现最佳患者管理至关重要。
