Song Xiaomei, Zhou Xiaoxin, Wang Hao, Guo Hong, Yang Jian
Research Center for Metabolic and Cardiovascular Diseases, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Department of Clinical Nutrition, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Front Nutr. 2025 Jan 7;11:1414124. doi: 10.3389/fnut.2024.1414124. eCollection 2024.
Patients with Crohn's disease (CD) commonly experience malnutrition. The Global Leadership Initiative on Malnutrition (GLIM) criteria, a novel approach to assessing malnutrition, has been validated in some diseases. However, there are limited studies in CD patients. This study aimed to investigate the applicability and effectiveness of the simplified GLIM criteria for evaluating the nutritional status of patients with Crohn's disease. Additionally, it sought to evaluate the correlation between malnutrition defined by simplified GLIM and clinical outcomes.
A retrospective cohort study was conducted with 386 patients with CD. Data were extracted from the medical records, including demographic and clinical characteristics. All patients were evaluated using the simplified GLIM criteria. The prevalence of malnutrition was reported and the relationship between malnutrition and clinical outcome was analyzed.
The prevalence of malnutrition among patients with CD was 73.6%, with 36.5% classified as moderate malnutrition and 37.0% classified as severe malnutrition. The malnourished group had significantly higher Crohn's Disease Activity Index (CDAI) scores compared to the non-malnourished group ( < 0.001). Furthermore, the malnutrition group exhibited significantly lower levels of specific nutritional indicators, including hemoglobin ( = 0.040), albumin ( = 0.015), and prealbumin ( = 0.021). The median duration of follow-up in the cohort was 15.2 weeks. The results indicated that malnutrition, as assessed by simplified GLIM, independently influenced endoscopic remission ( = 0.033). Additionally, the duration of disease ( = 0.021), C-reactive protein ( = 0.014) and prealbumin ( = 0.014) were independent factors influencing endoscopic remission in patients with CD.
Malnutrition identified using the simplified GLIM criteria is associated with age, CDAI, behavior, hemoglobin, and albumin, providing prognostic value for endoscopic remission in CD patients.
克罗恩病（CD）患者常出现营养不良。全球营养不良领导倡议（GLIM）标准是一种评估营养不良的新方法，已在某些疾病中得到验证。然而，针对CD患者的研究有限。本研究旨在探讨简化版GLIM标准在评估克罗恩病患者营养状况方面的适用性和有效性。此外，还试图评估简化版GLIM定义的营养不良与临床结局之间的相关性。
对386例CD患者进行回顾性队列研究。从病历中提取数据，包括人口统计学和临床特征。所有患者均使用简化版GLIM标准进行评估。报告营养不良的患病率，并分析营养不良与临床结局之间的关系。
CD患者中营养不良的患病率为73.6%，其中36.5%为中度营养不良，37.0%为重度营养不良。与非营养不良组相比，营养不良组的克罗恩病活动指数（CDAI）得分显著更高（<0.001）。此外，营养不良组的特定营养指标水平显著更低，包括血红蛋白（=0.040）、白蛋白（=0.015）和前白蛋白（=0.021）。队列中的中位随访时间为15.2周。结果表明，根据简化版GLIM评估的营养不良独立影响内镜缓解（=0.033）。此外，病程（=0.021）、C反应蛋白（=0.014）和前白蛋白（=0.014）是影响CD患者内镜缓解的独立因素。
使用简化版GLIM标准确定的营养不良与年龄、CDAI、病情、血红蛋白和白蛋白相关，可为CD患者的内镜缓解提供预后价值。
