Dawson N A, Barr C F, Alving B M
Am J Med. 1985 Apr;78(4):682-6. doi: 10.1016/0002-9343(85)90414-0.
Acquired dysfibrinogenemia has not been previously reported as a paraneoplastic marker for malignancy. This report describes the clinical course of a patient who at the time of diagnosis of nonmetastatic renal cell carcinoma had dysfibrinogenemia characterized by prolongation of the thrombin and Reptilase times and increased sialic acid content of the purified fibrinogen. The thrombin and Reptilase times returned toward normal values after nephrectomy but became abnormal with the development of nonhepatic metastases. It is concluded that acquired dysfibrinogenemia can be part of a paraneoplastic syndrome and is a sensitive plasma marker for tumor progression.
获得性纤维蛋白原异常血症此前尚未被报道为恶性肿瘤的副肿瘤标志物。本报告描述了一名患者的临床病程，该患者在诊断为非转移性肾细胞癌时出现纤维蛋白原异常血症，其特征为凝血酶时间和爬虫酶时间延长，以及纯化纤维蛋白原的唾液酸含量增加。肾切除术后，凝血酶时间和爬虫酶时间恢复至正常水平，但随着非肝转移的出现又变得异常。结论是，获得性纤维蛋白原异常血症可能是副肿瘤综合征的一部分，并且是肿瘤进展的一个敏感血浆标志物。
