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小儿贝尔麻痹症与新冠病毒病之间存在关联吗?

Is There an Association between Bell Palsy in Pediatric Patients and COVID-19?

作者信息

El-Deeb Mohamed E, Elzayat Saad, Salamah Abeer, Gamal Ali, Elgamal Shimaa, El-Sobki Ahmed

机构信息

Department of Otorhinolaryngology, Head and Neck Surgery, Kafrelsheikh University Hospital, Faculty of Medicine, Kafrelsheikh University, Kafr El Sheikh, Kafr El Sheikh Governorate, Egypt.

Department of Pediatrics, Faculty of Medicine, Kafrelsheikh University, Kafr El Sheikh, Kafr El Sheikh Governorate, Egypt.

出版信息

Int Arch Otorhinolaryngol. 2025 Jan 23;29(1):1-8. doi: 10.1055/s-0044-1789197. eCollection 2025 Jan.

Abstract

Bell palsy (BP) is an acquired, idiopathic facial palsy linked to lower motor neuron malfunction of the seventh cranial nerve. Several studies have identified BP as one of the many neuropathies that coronavirus disease 2019 (COVID-19) patients have developed, while other studies disagree.  To study if there is an association between BP in pediatric patients and COVID-19, and to examine the pattern of recovery in all pediatric cases of BP during the COVID-19 pandemic.  We performed a prospective cohort study on pediatric patients with acute onset unilateral facial weakness of unknown etiology (BP) during the pandemic period. All included patients were submitted to a reverse transcription-polymerase chain reaction (RT-PCR) test through nasopharyngeal and oropharyngeal swabs for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the time of the BP diagnosis.  No significant differences were found regarding COVID-19 infection and recovery from BP at the first, third, or sixth months of follow-up. According to the results, it seems that there is no association between COVID-19 infection and facial palsy; however, the patients infected with COVID-19 in the sample experienced a rapid, early recovery from BP. The mean incidence of BP in 5 years (2017-2021) was of 1.73/100 thousand individuals, with a statistically insignificant change throughout the years.  We were not able to show any association between BP and COVID-19. The patients underwent follow-up for up to 6 months, and we studied their patterns of recovery from BP, which were like those observed before the pandemic.

摘要

贝尔麻痹(BP)是一种后天性特发性面神经麻痹,与第七对脑神经的下运动神经元功能障碍有关。多项研究已将BP确定为2019冠状病毒病(COVID-19)患者所患的众多神经病变之一,而其他研究则持不同意见。

为研究儿科患者的BP与COVID-19之间是否存在关联,并考察COVID-19大流行期间所有儿科BP病例的恢复模式。

我们对大流行期间病因不明的急性单侧面部无力(BP)的儿科患者进行了一项前瞻性队列研究。所有纳入的患者在BP诊断时均通过鼻咽和口咽拭子进行严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的逆转录-聚合酶链反应(RT-PCR)检测。

在随访的第一个月、第三个月或第六个月,关于COVID-19感染和从BP恢复方面未发现显著差异。根据结果,似乎COVID-19感染与面神经麻痹之间没有关联;然而,样本中感染COVID-19的患者从BP中恢复得很快且较早。5年(2017 - 2021年)期间BP的平均发病率为1.73/10万,多年来无统计学上的显著变化。

我们未能证明BP与COVID-19之间存在任何关联。患者接受了长达6个月的随访,我们研究了他们从BP恢复的模式,这些模式与大流行前观察到的相似。

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本文引用的文献

1
Surge of Bell's Palsy in the era of COVID-19: Systematic review.
Eur J Neurol. 2022 Aug;29(8):2526-2543. doi: 10.1111/ene.15371. Epub 2022 May 19.
2
A cluster of children with facial nerve palsy in a high prevalence area for COVID-19.
BMC Pediatr. 2021 Oct 25;21(1):470. doi: 10.1186/s12887-021-02831-9.
3
Clinical Prognostic Factors Associated with Good Outcomes in Pediatric Bell's Palsy.
J Clin Med. 2021 Sep 24;10(19):4368. doi: 10.3390/jcm10194368.
4
The Pattern of Anosmia in Non-hospitalized Patients in the COVID-19 Pandemic: A Cross-sectional Study.
Int Arch Otorhinolaryngol. 2021 Jul;25(3):e334-e338. doi: 10.1055/s-0041-1730303. Epub 2021 Jun 25.
5
A systematic review of Bell's Palsy as the only major neurological manifestation in COVID-19 patients.
J Clin Neurosci. 2021 Aug;90:284-292. doi: 10.1016/j.jocn.2021.06.016. Epub 2021 Jun 21.
6
Can isolated sudden sensorineural hearing loss (SSNHL) and idiopathic acute facial paralysis (Bell's palsy) be symptoms of COVID-19?
Am J Otolaryngol. 2021 Sep-Oct;42(5):103129. doi: 10.1016/j.amjoto.2021.103129. Epub 2021 Jun 29.
7
Incidence of Bell Palsy in Patients With COVID-19.
JAMA Otolaryngol Head Neck Surg. 2021 Aug 1;147(8):767-768. doi: 10.1001/jamaoto.2021.1266.
8
Can COVID-19 Cause Peripheral Facial Nerve Palsy?
SN Compr Clin Med. 2021;3(8):1707-1713. doi: 10.1007/s42399-021-00967-4. Epub 2021 May 22.
9
Increased incidence of idiopathic paediatric facial palsy during the coronavirus disease 2019 pandemic.
J Laryngol Otol. 2021 Aug;135(8):668-670. doi: 10.1017/S0022215121001353. Epub 2021 May 12.
10
Does the SARS-CoV-2 pandemic really increase the frequency of peripheral facial palsy?
Am J Otolaryngol. 2021 Sep-Oct;42(5):103032. doi: 10.1016/j.amjoto.2021.103032. Epub 2021 Apr 7.

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