Gao Yan, Zhao Sen, Yang Ailing
Capital University of Physical Education and Sports, Institute of Artificial Intelligence in Sports, Beijing 100191, China.
Beijing Institute of Technology, School of Aerospace Engineering, Beijing 100081, China.
Appl Bionics Biomech. 2025 Jan 15;2025:5634808. doi: 10.1155/abb/5634808. eCollection 2025.
Bone is one of the hardest tissues in the human body, but it can undergo microcracks under long-term and periodic mechanical loads. The Newton iterative method was used to calculate the steady state, and the effects of different inlet and outlet pressures, trabecular gap width and height, and microcrack's depth and width on the fluid shear stress (FSS) were studied, and the gradient of FSS inside the microcrack was analyzed. The results show that the pressure difference and trabecular gap heigh are positively correlated with the FSS (the linear correlation coefficients were 0.9768 and 0.96542, respectively). When the trabecular gap width was 100 μm, the peak of FSS decreased by 28.57% compared with 800 and 400 μm, and the gradient of FSS inside the microcrack was 0.1-0.4 Pa/mm. This study can help people more intuitively understand the internal fluid distribution of trabecular bone and provide a reliable theoretical basis for the subsequent construction of gradient FSS devices in vitro.
骨骼是人体中最坚硬的组织之一，但在长期周期性机械负荷作用下会出现微裂纹。采用牛顿迭代法计算稳态，并研究了不同进出口压力、小梁间隙宽度和高度以及微裂纹深度和宽度对流体剪切应力（FSS）的影响，分析了微裂纹内部FSS的梯度。结果表明，压力差和小梁间隙高度与FSS呈正相关（线性相关系数分别为0.9768和0.96542）。当小梁间隙宽度为100μm时，FSS峰值与800μm和400μm相比降低了28.57%，微裂纹内部FSS梯度为0.1-0.4Pa/mm。本研究有助于人们更直观地了解小梁骨内部流体分布情况，为后续体外构建梯度FSS装置提供可靠的理论依据。
