Olmer M, Gaultier J, Mercier P, Rampal M
Proc Eur Dial Transplant Assoc. 1979;16:372-6.
Anti-HLA immunisation has been studied in 130 patients treated by haemodialysis between 1969 and 1978. Until 1977 blood transfusions were restricted (number of transfusions per patient averaged 3.42 units). However 50% of the patients were found to be immunised. The frequency of immunisation was higher in women patients (63%) than in men (39.7%). This difference shows a good correlation with the frequency of pregnancies (r = 0.849). The percentage of immunisation increases in parallel with the number of months of dialysis (r = 0.95). The capacity to eliminate HBS Ag seems to be related to the capacity for anti-HLA immunisation: 64% of the patients transiently positive for HBS antigen develop anti-HLA antibodies and only 26.7% when antigenaemia is persistent. Since 1977, 24 patients have been transfused with two units of whole blood once a week for three weeks, every six months. Antibodies appeared in only seven of them who had been transfused some years ago. The GLA system and transplantation play a small part. The age and the type of nephropathy seem to have no effect. A few patients developed antibodies for no apparent reason. Possibly bacterial or viral infections, or venous allografts were responsible.
1969年至1978年间，对130例接受血液透析治疗的患者进行了抗HLA免疫研究。直到1977年，输血都受到限制（每位患者平均输血量为3.42单位）。然而，发现50%的患者产生了免疫反应。女性患者的免疫频率（63%）高于男性（39.7%）。这种差异与妊娠频率有良好的相关性（r = 0.849）。免疫百分比与透析月数平行增加（r = 0.95）。清除HBS Ag的能力似乎与抗HLA免疫能力有关：HBS抗原短暂阳性的患者中有64%产生抗HLA抗体，而抗原血症持续时只有26.7%产生。自1977年以来，24例患者每六个月接受一次输血，每周输两单位全血，共输三周。只有7例几年前输过血的患者出现了抗体。GLA系统和移植起的作用较小。年龄和肾病类型似乎没有影响。少数患者无缘无故产生了抗体。可能是细菌或病毒感染，或静脉同种异体移植所致。
