刘易斯血型系统对临床肾移植的影响。

Influence of the Lewis blood group system on clinical kidney transplantation.

作者信息

Fischer E, Lenhard V, Römer W, Dreikorn K, Schärer K, Roelcke D

出版信息

Proc Eur Dial Transplant Assoc. 1979;16:377-82.

Abstract

The different Lewis phenotypes were determined retrospectively in 201 kidney transplant recipients. Transplant survival rates in Lewis compatible recipients were significantly higher (p less than 0.0005) than in Lewis incompatible recipients. The improvement of transplant prognosis by matching for Lewis antigens was confirmed by a prospective study comprising 55 donor/recipient combinations. HLA matching had little benefit on transplant survival whereas survival rates are strikingly increased by Lewis compatibility. In the Lewis compatible but HLA mismatched group, graft survival was definitely higher than in the HLA matched but Lewis mismatched group. Our data indicate that Lewis antigens play an important role in transplant prognosis. Compatibility in the Lewis system should therefore be considered when recipients are selected.

摘要

对201名肾移植受者的Lewis血型表型进行了回顾性测定。Lewis血型匹配的受者移植存活率显著高于Lewis血型不匹配的受者（p<0.0005）。一项包含55对供体/受体组合的前瞻性研究证实，通过Lewis抗原匹配可改善移植预后。HLA匹配对移植存活益处不大，而Lewis血型匹配可显著提高存活率。在Lewis血型匹配但HLA不匹配的组中，移植物存活率肯定高于HLA匹配但Lewis血型不匹配的组。我们的数据表明，Lewis抗原在移植预后中起重要作用。因此，在选择受者时应考虑Lewis系统的相容性。