Pashkina Ekaterina, Bykova Maria, Berishvili Maria, Lazarev Yaroslav, Kozlov Vladimir
Research Institute of Fundamental and Clinical Immunology, 14, Yadrintsevskaya St., 630099 Novosibirsk, Russia.
Department of Clinical Immunology, Novosibirsk State Medical University, 52, Krasny Prospect, 630091 Novosibirsk, Russia.
Cells. 2025 Jan 7;14(2):61. doi: 10.3390/cells14020061.
In recent years, hyaluronic acid (HA) has attracted increasing attention as a promising biomaterial for the development of drug delivery systems. Due to its unique properties, such as high biocompatibility, low toxicity, and modifiability, HA is becoming a basis for the creation of targeted drug delivery systems, especially in the field of oncology. Receptors for HA overexpressed in subpopulations of cancer cells, and one of them, CD44, is recognized as a molecular marker for cancer stem cells. This review examines the role of HA and its receptors in health and tumors and analyzes existing HA-based delivery systems and their use in various types of cancer. The development of new HA-based drug delivery systems will bring new opportunities and challenges to anti-cancer therapy.
近年来，透明质酸（HA）作为一种用于药物递送系统开发的有前景的生物材料，受到了越来越多的关注。由于其独特的性质，如高生物相容性、低毒性和可修饰性，HA正成为创建靶向药物递送系统的基础，尤其是在肿瘤学领域。HA受体在癌细胞亚群中过表达，其中之一CD44被认为是癌症干细胞的分子标志物。本文综述了HA及其受体在健康和肿瘤中的作用，并分析了现有的基于HA的递送系统及其在各类癌症中的应用。新型基于HA的药物递送系统的开发将给抗癌治疗带来新的机遇和挑战。
