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用于癌症治疗的基于透明质酸的药物递送系统

Hyaluronic Acid-Based Drug Delivery Systems for Cancer Therapy.

作者信息

Pashkina Ekaterina, Bykova Maria, Berishvili Maria, Lazarev Yaroslav, Kozlov Vladimir

机构信息

Research Institute of Fundamental and Clinical Immunology, 14, Yadrintsevskaya St., 630099 Novosibirsk, Russia.

Department of Clinical Immunology, Novosibirsk State Medical University, 52, Krasny Prospect, 630091 Novosibirsk, Russia.

出版信息

Cells. 2025 Jan 7;14(2):61. doi: 10.3390/cells14020061.

DOI:10.3390/cells14020061
PMID:39851489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11764402/
Abstract

In recent years, hyaluronic acid (HA) has attracted increasing attention as a promising biomaterial for the development of drug delivery systems. Due to its unique properties, such as high biocompatibility, low toxicity, and modifiability, HA is becoming a basis for the creation of targeted drug delivery systems, especially in the field of oncology. Receptors for HA overexpressed in subpopulations of cancer cells, and one of them, CD44, is recognized as a molecular marker for cancer stem cells. This review examines the role of HA and its receptors in health and tumors and analyzes existing HA-based delivery systems and their use in various types of cancer. The development of new HA-based drug delivery systems will bring new opportunities and challenges to anti-cancer therapy.

摘要

近年来，透明质酸（HA）作为一种用于药物递送系统开发的有前景的生物材料，受到了越来越多的关注。由于其独特的性质，如高生物相容性、低毒性和可修饰性，HA正成为创建靶向药物递送系统的基础，尤其是在肿瘤学领域。HA受体在癌细胞亚群中过表达，其中之一CD44被认为是癌症干细胞的分子标志物。本文综述了HA及其受体在健康和肿瘤中的作用，并分析了现有的基于HA的递送系统及其在各类癌症中的应用。新型基于HA的药物递送系统的开发将给抗癌治疗带来新的机遇和挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddb5/11764402/84c9319c123f/cells-14-00061-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddb5/11764402/bbad2eec94e9/cells-14-00061-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddb5/11764402/ff21d71ca4ad/cells-14-00061-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddb5/11764402/84c9319c123f/cells-14-00061-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddb5/11764402/bbad2eec94e9/cells-14-00061-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddb5/11764402/ff21d71ca4ad/cells-14-00061-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddb5/11764402/84c9319c123f/cells-14-00061-g003.jpg

相似文献

[1]
Hyaluronic Acid-Based Drug Delivery Systems for Cancer Therapy.

Cells. 2025-1-7

[2]
Hyaluronic acid-based drug nanocarriers as a novel drug delivery system for cancer chemotherapy: A systematic review.

Daru. 2021-12

[3]
Advances in Hyaluronic Acid-Based Drug Delivery Systems.

Curr Drug Targets. 2016

[4]
Research Progress of Hyaluronic Acid-Coated Nanocarriers in Targeted Cancer Therapy.

Cancer Biother Radiopharm. 2025-5

[5]
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Mol Pharm. 2020-7-6

[6]
Hyaluronic Acid-Based pH-Sensitive Polymer-Modified Liposomes for Cell-Specific Intracellular Drug Delivery Systems.

Bioconjug Chem. 2017-12-12

[7]
Hyaluronic acid-nimesulide conjugates as anticancer drugs against CD44-overexpressing HT-29 colorectal cancer in vitro and in vivo.

Int J Nanomedicine. 2017-3-27

[8]
Evaluating the Efficiency of Hyaluronic Acid for Tumor Targeting via CD44.

Mol Pharm. 2019-5-1

[9]
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Acta Biomater. 2016-3

[10]
Hyaluronic acid-functionalized nanomedicines for CD44-receptors-mediated targeted cancer therapy: A review of selective targetability and biodistribution to tumor microenvironment.

Int J Biol Macromol. 2025-5

引用本文的文献

[1]
Feedback Loops Shape Oxidative and Immune Interactions in Hepatic Ischemia-Reperfusion Injury.

Antioxidants (Basel). 2025-7-31

[2]
Pancreatic cancer: failures and hopes-a review of new promising treatment approaches.

Explor Target Antitumor Ther. 2025-3-18

本文引用的文献

[1]
Harnessing the targeting potential of hyaluronic acid for augmented anticancer activity and safety of duvelisib-loaded nanoparticles in hematological malignancies.

Int J Biol Macromol. 2024-12

[2]
Dual-Prodrug-Based Hyaluronic Acid Nanoplatform Provides Cascade-Boosted Drug Delivery for Oxidative Stress-Enhanced Chemotherapy.

ACS Appl Mater Interfaces. 2024-9-25

[3]
Hyaluronic acid as a tumor progression agent and a potential chemotherapeutic biomolecule against cancer: A review on its dual role.

Int J Biol Macromol. 2024-8

[4]
Leukemic Stem Cells and Hematological Malignancies.

Int J Mol Sci. 2024-6-17

[5]
Hyaluronic Acid-Bilirubin Nanoparticles as a Tumor Microenvironment Reactive Oxygen Species-Responsive Nanomedicine for Targeted Cancer Therapy.

Int J Nanomedicine. 2024

[6]
Exploring the Progress of Hyaluronic Acid Hydrogels: Synthesis, Characteristics, and Wide-Ranging Applications.

Materials (Basel). 2024-5-18

[7]
CD44 and its implication in neoplastic diseases.

MedComm (2020). 2024-5-23

[8]
The bioengineering application of hyaluronic acid in tissue regeneration and repair.

Int J Biol Macromol. 2024-6

[9]
CD44: a cancer stem cell marker and therapeutic target in leukemia treatment.

Front Immunol. 2024

[10]
LYVE-1-expressing Macrophages Modulate the Hyaluronan-containing Extracellular Matrix in the Mammary Stroma and Contribute to Mammary Tumor Growth.

Cancer Res Commun. 2024-5-31

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