Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Medical Biology Research Centre, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Daru. 2021 Dec;29(2):439-447. doi: 10.1007/s40199-021-00416-6. Epub 2021 Sep 9.
Chemotherapy is the most common treatment strategy for cancer patients. Nevertheless, limited drug delivery to cancer cells, intolerable toxicity, and multiple drug resistance are constant challenges of chemotherapy. Novel targeted drug delivery strategies by using nanoparticles have attracted much attention due to reducing side effects and increasing drug efficacy. Therefore, the most important outcome of this study is to answer the question of whether active targeted HA-based drug nanocarriers have a significant effect on improving drug delivery to cancer cells.This study aimed to systematically review studies on the use of hyaluronic acid (HA)-based nanocarriers for chemotherapy drugs. The two databases MagIran and SID from Persian databases as well as international databases PubMed, WoS, Scopus, Science Direct, Embase, as well as Google Scholar were searched for human studies and cell lines and/or xenograft mice published without time limit until 2020. Keywords used to search included Nanoparticle, chemotherapy, HA, Hyaluronic acid, traditional medicine, natural medicine, chemotherapeutic drugs, natural compound, cancer treatment, and cancer. The quality of the studies was assessed by the STROBE checklist. Finally, studies consistent with inclusion criteria and with medium- to high-quality were included in the systematic review.According to the findings of studies, active targeted HA-based drug nanocarriers showed a significant effect on improving drug delivery to cancer cells. Also, the use of lipid nanoparticles with a suitable coating of HA have been introduced as biocompatible drug carriers with high potential for targeted drug delivery to the target tissue without affecting other tissues and reducing side effects. Enhanced drug delivery, increased therapeutic efficacy, increased cytotoxicity and significant inhibition of tumor growth, as well as high potential for targeted chemotherapy are also reported to be benefits of using HA-based nanocarriers for tumors with increased expression of CD44 receptor.
化疗是癌症患者最常见的治疗策略。然而，向癌细胞输送有限的药物、无法忍受的毒性和多重耐药性是化疗的持续挑战。新型靶向药物递送策略，使用纳米颗粒，由于减少副作用和提高药物疗效，因此引起了广泛关注。因此，本研究最重要的结果是回答以下问题：主动靶向基于 HA 的药物纳米载体是否对提高癌细胞的药物输送具有显著效果。
本研究旨在系统综述基于透明质酸（HA）的纳米载体用于化疗药物的研究。两个 Persian 数据库 MagIran 和 SID 以及国际数据库 PubMed、WoS、Scopus、Science Direct、Embase 以及 Google Scholar 用于搜索无时间限制的人类研究和细胞系和/或异种移植小鼠，直到 2020 年。用于搜索的关键词包括纳米颗粒、化疗、HA、透明质酸、传统医学、天然药物、化疗药物、天然化合物、癌症治疗和癌症。研究质量通过 STROBE 清单进行评估。最后，将符合纳入标准且具有中等到高质量的研究纳入系统综述。
根据研究结果，主动靶向基于 HA 的药物纳米载体在提高药物向癌细胞的输送方面显示出显著效果。此外，还介绍了具有适当 HA 涂层的脂质纳米颗粒作为生物相容性药物载体，具有向靶组织靶向药物输送的高潜力，而不会影响其他组织并减少副作用。还报道了增强的药物输送、增加的治疗效果、增加的细胞毒性和肿瘤生长的显著抑制以及针对 CD44 受体表达增加的肿瘤进行靶向化疗的高潜力，也是使用基于 HA 的纳米载体的益处。
