移植前的细胞毒性抗体不会将肾移植受者分为反应者和无反应者群体。
Pretransplant cytotoxic antibodies do not segregate kidney transplant recipients into responder and non-responder groups.
作者信息
Vincenti F, Amend W, Feduska N, Duca R, Salvatierra O
出版信息
Proc Eur Dial Transplant Assoc. 1979;16:419-25.
In a study of 687 primary cadaver transplants, we found no correlation between the degree of presensitisation and graft survival. Graft survival was adversely affected in non-transfused recipients and was significantly improved in trnasfused recipients, independent of the level of presensitisation (63%, 61%, 67% at one year for patients with 0-10%, 11-50%, and 51-100% preformed cytotoxic antibodies, respectively). Humoral presensitisation to HLA antigens does not reflect the immunoresponsiveness of the host to the renal allograft, but it may prolong the wait for a compatible donor kidney.
在一项对687例尸体原位移植的研究中，我们发现预致敏程度与移植物存活之间无相关性。未输血受者的移植物存活受到不利影响，而输血受者的移植物存活则显著改善，与预致敏水平无关（分别有0 - 10%、11 - 50%和51 - 100%预先形成细胞毒性抗体的患者，术后一年移植物存活率分别为63%、61%和67%）。对HLA抗原的体液预致敏并不反映宿主对肾移植的免疫反应性，但可能会延长等待合适供体肾的时间。
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