Yavin Hagai, Prasad Mark, Gordon Jonathan, Aksu Tolga, Huang Henry D
Department of Cardiology, Rush University Medical Center, Chicago, IL 60612, USA.
Department of Cardiology, Yeditepe University Hospital, 34755 Istanbul, Turkey.
J Cardiovasc Dev Dis. 2024 Dec 30;12(1):10. doi: 10.3390/jcdd12010010.
Pulsed field ablation (PFA) is a catheter-based procedure that utilizes short high voltage and short-duration electrical field pulses to induce tissue injury. The last decade has yielded significant scientific progress and quickened interest in PFA as an energy modality leading to the emergence of the clinical use of PFA technologies for the treatment of atrial fibrillation. It is generally agreed that more research is needed to improve our biophysical understanding of PFA for clinical cardiac applications as well as its potential as a potential alternative energy source to thermal ablation modalities for the treatment of other arrhythmias. In this review, we discuss the available preclinical and clinical evidence for PFA for atrial fibrillation, developments for ventricular arrhythmia (VA) ablation, and future perspectives.
脉冲场消融（PFA）是一种基于导管的手术，它利用短时间的高电压和短持续时间的电场脉冲来诱导组织损伤。在过去十年中，该领域取得了重大科学进展，人们对PFA作为一种能量模式的兴趣迅速增加，这导致了PFA技术在临床中用于治疗心房颤动。人们普遍认为，需要进行更多研究，以增进我们对PFA在临床心脏应用中的生物物理学理解，以及其作为热消融模式的潜在替代能源用于治疗其他心律失常的潜力。在这篇综述中，我们讨论了PFA治疗心房颤动的现有临床前和临床证据、室性心律失常（VA）消融的进展以及未来展望。
