肝移植受者中抗抗体的血清学特征

Serological Profile of Anti- Antibodies in Liver Transplant Recipients.

作者信息

Pintos Gabriella Beltrame, Pires Francielly Camilla Bazílio Laurindo, Zini Nathália, da Silva Rita Cássia Martins Alves, Silva Junior Francisco Inaldo Mendes, da Silva Renato Ferreira, Pinho Tainara Souza, de Mattos Luiz Carlos, Brandão Cinara Cássia

机构信息

Faculdade de Medicina de São José do Rio Preto (FAMERP), Avenida Brigadeiro Faria Lima, 5416, Vila São Pedro, São José do Rio Preto 15090-000, SP, Brazil.

Hospital de Base-Fundação Faculdade Regional de Medicina (HB-FUNFARME), São José do Rio Preto 15090-000, SP, Brazil.

出版信息

Trop Med Infect Dis. 2025 Jan 9;10(1):18. doi: 10.3390/tropicalmed10010018.

DOI:10.3390/tropicalmed10010018

PMID:39852669

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11769296/

Abstract

, a globally distributed obligatory intracellular opportunistic parasite that has infected one third of the world population, has different transmission routes including via organ transplantation. The liver has emerged as a frequent transplanted organ in which the transmission of can occur between seropositive donors and seronegative recipients. Allied with immunosuppressive therapy, the presence of latent infection in recipients elevates the risk of severe toxoplasmosis. The goal of this study was to evaluate the demographic, clinical, epidemiological, and anti- antibody profiles in liver transplant recipients. All demographic, clinical, epidemiological, and serological data were obtained from the electronic medical records of liver transplant recipients from the Liver Transplantation Service of the Hospital de Base in São José do Rio Preto, Brazil, from 2008 to 2018. Data from 48 eligible recipients (females: n = 17; males: n = 31) were evaluated. The recipients were grouped according to their serological profiles (G1: IgM-/IgG-; G2: IgM-/IgG+; G3: IgM+/IgG+; G4: IgM+/IgG-). The overall mean age was 55.3 (±15.3) years; the age difference between women (42.7 ± 17 years) and men (62.2 ± 10.9 years) was statistically significant (-value > 0.0001). The percentages of the serological profiles were 20 (n = 41.7%), 26 (n = 54.1%), and 2 (n = 4.2%) for G1, G2, and G3, respectively. No recipient had a serological profile for G4. Hepatosplenomegaly (47.9%), fever (35.4%), encephalopathy (20.8%), and headache (16.7%) were commonly observed symptoms. No statistically significant differences were observed between the serological group and clinical data (-value = 0.953). The percentages of coinfection by with hepatitis A, B, and C were 47.9%, 20.8%, and 12.5%, respectively. About 41.7% of the recipients later died. The data demonstrate that infection by is common in liver transplant recipients, and it is not associated with the analyzed demographic, clinical, and epidemiological data.

摘要

作为一种全球分布的 obligatory 细胞内机会性寄生虫，已感染全球三分之一的人口，它有不同的传播途径，包括通过器官移植。肝脏已成为一种常见的移植器官，在血清学阳性供体和血清学阴性受体之间可能发生其传播。与免疫抑制治疗相关，受体中潜伏感染的存在增加了严重弓形虫病的风险。本研究的目的是评估肝移植受者的人口统计学、临床、流行病学和抗抗体谱。所有人口统计学、临床、流行病学和血清学数据均来自巴西里约普雷图圣若泽医院肝脏移植服务中心 2008 年至 2018 年肝移植受者的电子病历。对 48 名符合条件的受者（女性：n = 17；男性：n = 31）的数据进行了评估。受者根据其血清学谱分组（G1：IgM-/IgG-；G2：IgM-/IgG+；G3：IgM+/IgG+；G4：IgM+/IgG-）。总体平均年龄为 55.3（±15.3）岁；女性（42.7±17 岁）和男性（62.2±10.9 岁）之间的年龄差异具有统计学意义（-值>0.0001）。G1、G2 和 G3 的血清学谱百分比分别为 20（n = 41.7%）、26（n = 54.1%）和 2（n = 4.2%）。没有受者具有 G4 的血清学谱。肝脾肿大（47.9%）、发热（35.4%）、脑病（20.8%）和头痛（16.7%）是常见症状。血清学组和临床数据之间未观察到统计学显著差异（-值 = 0.953）。与甲型、乙型和丙型肝炎合并感染的百分比分别为 47.9%、20.8%和 12.5%。约 41.7%的受者后来死亡。数据表明，在肝移植受者中，感染很常见，并且它与所分析的人口统计学、临床和流行病学数据无关。