光学相干断层扫描在亨廷顿舞蹈病中的应用——一种未来潜在的神经退行性变生物标志物？
Optical Coherence Tomography in Huntington's Disease-A Potential Future Biomarker for Neurodegeneration?
作者信息
Cerejo Clancy, De Cleene Nicolas, Mandler Elias, Schwarzová Katarina, Labrecque Samuel, Mahlknecht Philipp, Krismer Florian, Djamshidian Atbin, Seppi Klaus, Heim Beatrice
机构信息
Department of Neurology, Medical University of Innsbruck, Innsbruck 6020, Austria.
Department of Neurology, Hospital Kufstein, Kufstein 6330, Austria.
出版信息
Neurol Int. 2025 Jan 20;17(1):13. doi: 10.3390/neurolint17010013.
Huntington's disease (HD) is a progressive neurodegenerative disorder for which, until now, only symptomatic treatment has been available. Lately, there have been multiple ongoing clinical trials targeting therapeutic agents for preventing disease onset or slowing disease progression in HD. These studies are in constant need of reliable biomarkers for neurodegeneration in HD. In recent years, retinal biomarkers have attracted significant attention in neurodegenerative disorders. Likewise, optical coherence tomography (OCT) is being evaluated as a potential biomarker in HD. In this article, we review the existing literature on OCT as a biomarker for neurodegeneration in HD.
亨廷顿舞蹈症（HD）是一种进行性神经退行性疾病，迄今为止，针对该病只有对症治疗方法。最近，有多项正在进行的临床试验针对用于预防HD疾病发作或减缓疾病进展的治疗药物。这些研究一直需要用于HD神经退行性变的可靠生物标志物。近年来，视网膜生物标志物在神经退行性疾病中引起了极大关注。同样，光学相干断层扫描（OCT）正在作为HD的一种潜在生物标志物进行评估。在本文中，我们综述了有关OCT作为HD神经退行性变生物标志物的现有文献。
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