阿根廷亨廷顿舞蹈病患者的光学相干断层扫描（OCT）研究
Optical coherence tomography (OCT) study in Argentinean Huntington's disease patients.
作者信息
Gatto Emilia, Parisi Virginia, Persi Gabriel, Fernandez Rey Estela, Cesarini Martin, Luis Etcheverry José, Rivera Pablo, Squitieri Ferdinando
机构信息
a Department of Neurology , Sanatorio de la Trinidad Mitre , Buenos Aires , Argentina.
b Department of Movement Disorders , Fundación INEBA , Buenos Aires , Argentina.
出版信息
Int J Neurosci. 2018 Dec;128(12):1157-1162. doi: 10.1080/00207454.2018.1489807. Epub 2018 Aug 21.
BACKGROUND
Huntington's disease (HD) is a genetic, rare and progressive neurodegenerative disorder that causes motor and cognitive impairment in midlife patients. Although retinal damage was observed in animal HD models and in patients with other neurodegenerative diseases, we still need confirmation of impairment in HD patients. Optical coherence tomography (OCT) is a non-invasive methodology that analyses the retinal nerve fibre layers (RNFL) and could reflect processes of neurodegeneration.
METHODS
A cross-sectional study with 14 HD patients who underwent a spectral domain OCT. Results were compared with a control group. Demographic data were also obtained.
RESULTS
Temporal and superior RNFL sectors in HD showed a significant RNFL thinning compared with a control group. However, no differences were identified in mean total RNFL thickness between HD patients and controls.
CONCLUSIONS
OCT is a rapid and non-invasive technique that can be investigated in larger cohorts of patients to assess its potential role as a biomarker in HD patients.
背景
亨廷顿舞蹈症（HD）是一种遗传性、罕见的进行性神经退行性疾病，会导致中年患者出现运动和认知障碍。尽管在动物HD模型和其他神经退行性疾病患者中观察到了视网膜损伤，但我们仍需要证实HD患者存在损伤。光学相干断层扫描（OCT）是一种非侵入性方法，可分析视网膜神经纤维层（RNFL），并能反映神经退行性变过程。
方法
对14名接受光谱域OCT检查的HD患者进行横断面研究。将结果与对照组进行比较。还获取了人口统计学数据。
结果
与对照组相比，HD患者的颞侧和上方RNFL扇形区域显示出明显的RNFL变薄。然而，HD患者与对照组之间的平均总RNFL厚度没有差异。
结论
OCT是一种快速且非侵入性的技术，可在更大的患者队列中进行研究，以评估其作为HD患者生物标志物的潜在作用。
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