He Qing, Xu Yang, Li Yilan, Zhu Pinting, Luo Lei
Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China.
Institute of Public Health, Guangzhou Medical University and Guangzhou Center for Disease Control and Prevention, Guangzhou 511436, China.
Vaccines (Basel). 2024 Dec 30;13(1):23. doi: 10.3390/vaccines13010023.
Seropositivity study of Varicella in Healthy Populations in Guangzhou, China. Infection with varicella-zoster virus (VZV) leads to skin and mucous membranes blisters and the complications can be life threatening. A seroepidemiological study conducted from 2020 to 2022 in Guangzhou, China, aimed to evaluate varicella antibody levels. We measured varicella antibody concentrations using an enzyme-linked immunosorbent assay. A total of 3300 people were enrolled in the study. The mean varicella antibody level was 171.2 mIU/mL (95% CI: 158.9, 184.4), with an overall positivity rate of 67.00% (95% CI: 65.37, 68.60). The mean level of those positive subjective was 581.2 mIU/mL (95% CI: 552.3, 611.5). Varicella antibody levels were found to be influenced by age, vaccination dosage, and history of varicella infection. Antibody level increased with age and the number of vaccinations. The antibody induced by the varicella vaccine remained at protective levels for at least 6 years post-vaccination. We recommend two doses of the varicella vaccine for both children and adults and the integration of the varicella vaccine into the national routine immunization program.
中国广州健康人群水痘血清学阳性研究。水痘带状疱疹病毒（VZV）感染会导致皮肤和黏膜出现水疱，其并发症可能危及生命。2020年至2022年在中国广州进行的一项血清流行病学研究旨在评估水痘抗体水平。我们使用酶联免疫吸附测定法测量水痘抗体浓度。共有3300人参与该研究。水痘抗体平均水平为171.2 mIU/mL（95%可信区间：158.9，184.4），总体阳性率为67.00%（95%可信区间：65.37，68.60）。阳性人群的平均水平为581.2 mIU/mL（95%可信区间：552.3，611.5）。发现水痘抗体水平受年龄、疫苗接种剂量和水痘感染史影响。抗体水平随年龄和接种次数增加。水痘疫苗诱导产生的抗体在接种后至少6年保持在保护水平。我们建议儿童和成人都接种两剂水痘疫苗，并将水痘疫苗纳入国家常规免疫规划。
