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通过应用补充饲料减少抗生素使用来控制仔猪新生腹泻——一项随机对照农场试验

Control of Neonatal Diarrhea in Piglets with Reduced Antibiotic Use by Application of a Complementary Feed-A Randomized Controlled Farm Trial.

作者信息

Sall Klaus K, Foldager Leslie, Delf Charlotte, Christensen Sigurd J, Agerley Michael N, Havn Kristian T, Pedersen Carsten

机构信息

Sall&Sall Advisors, DK-8220 Brabrand, Denmark.

Newtrifeed ApS, DK-6372 Bylderup-Bov, Denmark.

出版信息

Vet Sci. 2025 Jan 10;12(1):42. doi: 10.3390/vetsci12010042.

DOI:10.3390/vetsci12010042
PMID:39852918
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11769454/
Abstract

The objective of this farm trial was to investigate if the consumption of antibiotics could be reduced when piglets showing early signs of neonatal diarrhea were treated with an oral dose of tannin extract derived from sweet chestnut wood. The farm had a very high incidence of neonatal diarrhea among gilt litters. Gilts were randomized into test or control groups in a 1:1 ratio to compare the consumption of antibiotics used for piglets and piglet mortality during the four-week trial period. Control litters were treated with the oral antibiotic paromomycin, while test litters were treated with the complementary feed O-Nella-Protect. The farm trial included 18 gilt litters comprising 254 piglets. In the control group, 100% of the piglets received antibiotic treatment. In the test group, consumption of antibiotics used against diarrhea was reduced by 84% ( = 0.001) and consumption of antibiotics used for other illnesses was reduced by 45% ( = 0.045). In both test and control groups, six piglets died. Microbiological analysis identified both potential bacterial and viral pathogens. In conclusion, the farm trial indicates that even under the challenge of potentially serious bacterial and viral pathogens, a complimentary feed containing a tannin extract can support piglet health and reduce antibiotic consumption.

摘要

本次猪场试验的目的是研究,当给出现新生仔猪腹泻早期症状的仔猪口服一剂源自甜栗木的单宁提取物时,抗生素的使用量是否能够减少。该猪场后备母猪产仔的新生仔猪腹泻发病率非常高。在为期四周的试验期内,将后备母猪按1:1的比例随机分为试验组和对照组,以比较仔猪抗生素的使用量和仔猪死亡率。对照组仔猪接受口服抗生素巴龙霉素治疗,而试验组仔猪则用补充饲料O-Nella-Protect进行治疗。该猪场试验包括18窝后备母猪产的254头仔猪。在对照组中,100%的仔猪接受了抗生素治疗。在试验组中,用于治疗腹泻的抗生素使用量减少了84%(P = 0.001),用于治疗其他疾病的抗生素使用量减少了45%(P = 0.045)。试验组和对照组均有6头仔猪死亡。微生物分析确定了潜在的细菌和病毒病原体。总之,该猪场试验表明,即使面临潜在严重细菌和病毒病原体的挑战,含有单宁提取物的补充饲料也可以维持仔猪健康并减少抗生素的使用量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3867/11769454/f2c597eba8f5/vetsci-12-00042-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3867/11769454/f2c597eba8f5/vetsci-12-00042-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3867/11769454/f2c597eba8f5/vetsci-12-00042-g001.jpg

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