Gonzaga Luana Almeida, Porto Andrey Alves, Takahashi Carolina, Gomes Rayana Loch, Vanderlei Luiz Carlos Marques, Valenti Vitor Engrácia
Postgraduate Program in Movement Sciences, Universidade Estadual Paulista (UNESP), Presidente Prudente, São Paulo, Brazil.
Faculty of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, Mato Grosso do Sul, Brazil.
Eur J Nutr. 2025 Jan 24;64(2):67. doi: 10.1007/s00394-025-03582-4.
This study aimed to evaluate the acute effects of beetroot extract and resveratrol supplementation (isolated and combined) on cardiac autonomic modulation and cardiovascular parameters recovery after exercise in individuals with coronary artery disease (CAD).
14 males with CAD were submitted to 4 protocols consisting of 30 min (min) of rest, 30 min of aerobic exercise on a treadmill (60% of the heart rate reserve HRR), followed by 30 min of recovery. Before each protocol, the subjects consumed 500 mg of starch (placebo protocol), 500 mg of beetroot (beetroot protocol), or 500 mg of resveratrol (resveratrol protocol), or 500 mg of beetroot and 500 mg of resveratrol (combined protocol). Heart rate variability (HRV) indices and cardiorespiratory parameters were determined at different times during the protocols.
Regarding HR, significantly higher values about rest in the placebo protocol at all recovery moments (1st to 30th min) were observed. Significant differences were observed in the other protocols (beetroot, resveratrol and combined) from the first to the 20th min recovery. For SBP, significantly higher values concerning rest were observed at the first minute of recovery for all protocols. No differences were found for the HRV index between time and protocols.
The single supplementation of beetroot and resveratrol (isolated and combined) did not alter HRV and cardiovascular parameter responses between protocols. The consumption of beetroot extract and resveratrol enhanced vagal modulation and heart rate recovery compared to rest.
本研究旨在评估甜菜根提取物和白藜芦醇补充剂（单独及联合使用）对冠心病（CAD）患者运动后心脏自主神经调节和心血管参数恢复的急性影响。
14名CAD男性患者接受4种方案，包括30分钟休息、30分钟在跑步机上进行有氧运动（心率储备[HRR]的60%），随后30分钟恢复。在每个方案之前，受试者分别服用500毫克淀粉（安慰剂方案）、500毫克甜菜根（甜菜根方案）、500毫克白藜芦醇（白藜芦醇方案）或500毫克甜菜根和500毫克白藜芦醇（联合方案）。在方案的不同时间测定心率变异性（HRV）指标和心肺参数。
关于心率（HR），在所有恢复时刻（第1至30分钟），安慰剂方案中休息时的HR值显著更高。在第1至20分钟恢复期间，其他方案（甜菜根、白藜芦醇和联合方案）观察到显著差异。对于收缩压（SBP），所有方案在恢复的第一分钟时休息时的SBP值显著更高。时间和方案之间的HRV指数未发现差异。
单独补充甜菜根和白藜芦醇（单独及联合）在各方案之间未改变HRV和心血管参数反应。与休息相比，食用甜菜根提取物和白藜芦醇可增强迷走神经调节和心率恢复。
