Alterations of the retina in chick embryos induced by systemic alpha-bungarotoxin application.

The application of alpha-bungarotoxin onto the chorio-allantoic membrane of chick embryos between the 11th and 18th day of incubation leads to alterations of retinal development. The most significant qualitative change is the appearance of retinal rosettes formed by receptor cells. These rosettes are infoldings of the receptor cell layer. Quantitatively, an enlargement in volume of the receptor and outer nuclear layer can be found together with a simultaneous decrease of the other retinal layers. The toxin seems to suspend the naturally occurring nerve cell death in the receptor cell population