Shingu K, Osawa M, Fukuda K, Mori K
Anesthesiology. 1985 Apr;62(4):502-4. doi: 10.1097/00000542-198504000-00021.
The time course of nitrous oxide analgesia was studied in rats with a behavioral criterion, the tail-flick test to radiant heat. All rats were placed individually in a Plexiglas tube and exposed to either nitrous oxide, 75% in oxygen, or room air (control) for 2 hr. Analgesic potency was evaluated by prolongation of the time required to induce tail-flick. Although individual animals showed variability in the tail-flick time during exposure to nitrous oxide, no animal showed a tendency toward the development of tolerance, and a statistically significant sustained prolongation of tail-flick time was produced.
采用行为学标准即辐射热甩尾试验，对大鼠一氧化二氮镇痛的时程进行了研究。将所有大鼠单独置于有机玻璃管中，使其暴露于含75%氧气的一氧化二氮或室内空气（对照）中2小时。通过延长诱发甩尾所需的时间来评估镇痛效力。虽然个体动物在暴露于一氧化二氮期间甩尾时间存在差异，但没有动物表现出耐受性发展的趋势，并且产生了具有统计学意义的甩尾时间持续延长。
