含苯乙烯-二乙烯基苯吸附剂的药筒中碘造影剂的吸附作用

Iodinated Contrast Adsorption in Cartridges With Styrene-Divinylbenzene Sorbent.

作者信息

Reis Thiago, Ramírez-Guerrero Gonzalo, Pecoits-Filho Roberto, Lorenzin Anna, de Cal Massimo, Corradi Valentina, Klinkmann Gerd, Ronco Federico, Neves Francisco A R, Bellomo Rinaldo, Ronco Claudio

机构信息

Laboratory of Molecular Pharmacology, Faculty of Health Sciences, University of Brasília, Asa Norte, Brasília, Brazil.

Division of Nephrology, University of São Paulo Medical School, São Paulo, Brazil.

出版信息

Artif Organs. 2025 May;49(5):813-819. doi: 10.1111/aor.14949. Epub 2025 Jan 24.

DOI:10.1111/aor.14949

PMID:39854063

Abstract

BACKGROUND

Contrast-associated acute kidney injury (CA-AKI) is frequent in patients with chronic kidney disease who are submitted to cardiac endovascular procedures using iodinated contrast. In hemoadsorption, cartridges containing styrene-divinylbenzene sorbent resin are applied to remove substances from the blood through an extracorporeal circuit. Importantly, iodinated contrast is also removed via adsorption. We aimed to determine the adsorptive kinetics of the iodinated contrast medium iohexol using a 1:3 scale model of the HA380 cartridge.

METHODS

An experimental in vitro study utilizing a closed-loop extracorporeal circuit with an interposed sorbent cartridge. A solution spiked with iohexol was recirculated for 60 min. Samples for the measurement of iohexol were drawn at 0, 5, 10, 15, 20, 30, 40, and 60 min. The experiment was carried out twice.

RESULTS

In experiments 1 and 2, the reduction ratio after 60 min was 53.0% and 53.1%, respectively. In experiment 1, iohexol clearance was 46.79 mL/min during the first 5 min and decayed to 3.57 mL/min during the last 20 min. In experiment 2, iohexol clearance was 46.72 mL/min and decayed to 3.87 mL/min during the last 20 min. The ratio of adsorbate/sorbent was 155 mg/g.

CONCLUSION

A 1:3 scale model of the HA380 cartridge efficiently removes iodinated contrast in a clinical-scale in vitro circuit. These findings provide a rationale for hemoadsorption as an intervention in clinical trials to prevent or attenuate CA-AKI.

摘要

背景

在接受使用碘化造影剂的心脏血管内介入手术的慢性肾脏病患者中，造影剂相关急性肾损伤（CA-AKI）很常见。在血液吸附中，含有苯乙烯-二乙烯基苯吸附树脂的 cartridges 通过体外循环用于从血液中去除物质。重要的是，碘化造影剂也可通过吸附去除。我们旨在使用 HA380 cartridges 的 1:3 比例模型确定碘化造影剂碘海醇的吸附动力学。

方法

一项体外实验研究，利用带有插入吸附 cartridge 的闭环体外循环。将加有碘海醇的溶液再循环 60 分钟。在 0、5、10、15、20、30、40 和 60 分钟时抽取用于测量碘海醇的样本。实验进行了两次。

结果

在实验 1 和 2 中，60 分钟后的降低率分别为 53.0%和 53.1%。在实验 1 中，最初 5 分钟内碘海醇清除率为 46.79 mL/min，并在最后 20 分钟内降至 3.57 mL/min。在实验 2 中，碘海醇清除率为 46.72 mL/min，并在最后 20 分钟内降至 3.87 mL/min。吸附质/吸附剂的比例为 155 mg/g。