Sk Md Salauddin, Mwangomo Ruth, Daniel Luke, Gilmore Jordon
Department of Bioengineering, Clemson University, Clemson, South Carolina, USA.
J Biomed Mater Res B Appl Biomater. 2025 Feb;113(2):e35513. doi: 10.1002/jbm.b.35513.
Application of one-dimensional nanofibers have witnessed exponential growth over the past few decades and are still emerging with their excellent physicochemical and electrical properties. The driving force behind this intriguing transition lies in their unique high surface-to-volume ratio, ubiquitous nanodomains, improved tensile strength, and flexibility to incorporate deliberate functionalities required for specific and advanced applications. Besides numerous benefits, nanomaterials may adversely interact with biological tissues and potentially be cytotoxic and carcinogenic. However, precisely engineered design can outperform the risk with myriad benefits. Wound care technologies are evolving, and products involved in wound care management have a yearly market value of $15-22 billion. Solution blow spinning (SBS) is a facile technique to synthesize biocompatible nanofibers with scalable processing variables for multidirectional biomedical applications. SBS is feasible for a wide range of thermoplastic polymers and nanomaterials to fabricate nanocomposites. This review will focus on the relevance of SBS technology for wound care, including dressings, drug delivery, tissue engineering scaffolds, and sensors.
在过去几十年中，一维纳米纤维的应用呈指数级增长，并且凭借其优异的物理化学和电学性能仍在不断涌现。这种引人注目的转变背后的驱动力在于其独特的高比表面积、普遍存在的纳米域、提高的拉伸强度以及纳入特定和先进应用所需的有意功能的灵活性。除了众多益处外，纳米材料可能会与生物组织产生不利相互作用，并可能具有细胞毒性和致癌性。然而，精确设计的工程可以在带来众多益处的同时胜过风险。伤口护理技术正在不断发展，参与伤口护理管理的产品每年的市场价值为150亿至220亿美元。溶液吹纺（SBS）是一种简便的技术，可通过可扩展的加工变量合成生物相容性纳米纤维，用于多方向生物医学应用。SBS对于制造纳米复合材料的多种热塑性聚合物和纳米材料是可行的。本综述将重点关注SBS技术在伤口护理方面的相关性，包括敷料、药物递送、组织工程支架和传感器。
