细胞外囊泡相关的miR-ERIA在糖尿病伤口愈合中发挥巨噬细胞的抗血管生成作用。

Extracellular Vesicle-Associated miR-ERIA Exerts the Antiangiogenic Effect of Macrophages in Diabetic Wound Healing.

作者信息

Zeng Tingting, Sun Kan, Mai Lifang, Hong Xiaosi, He Xiaodan, Lin Weijie, Chen Sifan, Yan Li

机构信息

Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Guangdong Clinical Research Center for Metabolic Diseases, Guangzhou, China.

出版信息

Diabetes. 2025 Apr 1;74(4):596-610. doi: 10.2337/db24-0701.

An understanding of cell interactions is needed to identify therapeutic targets for diabetic cutaneous ulcers. We explored extracellular vesicles after treatment with advanced glycation end products (AGEs-EVs) derived from macrophages that can suppress diabetic cutaneous wound healing. We found that a novel miRNA enriched in AGEs-EVs (miR-ERIA) suppresses the migration and tube formation of vascular endothelial cells by targeting helicase with zinc finger 2. miR-ERIA offers a potential therapeutic target for diabetic cutaneous ulcers.