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细胞外囊泡相关的miR-ERIA在糖尿病伤口愈合中发挥巨噬细胞的抗血管生成作用。

Extracellular Vesicle-Associated miR-ERIA Exerts the Antiangiogenic Effect of Macrophages in Diabetic Wound Healing.

作者信息

Zeng Tingting, Sun Kan, Mai Lifang, Hong Xiaosi, He Xiaodan, Lin Weijie, Chen Sifan, Yan Li

机构信息

Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Guangdong Clinical Research Center for Metabolic Diseases, Guangzhou, China.

出版信息

Diabetes. 2025 Apr 1;74(4):596-610. doi: 10.2337/db24-0701.

DOI:10.2337/db24-0701
PMID:39854218
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11926273/
Abstract

An understanding of cell interactions is needed to identify therapeutic targets for diabetic cutaneous ulcers. We explored extracellular vesicles after treatment with advanced glycation end products (AGEs-EVs) derived from macrophages that can suppress diabetic cutaneous wound healing. We found that a novel miRNA enriched in AGEs-EVs (miR-ERIA) suppresses the migration and tube formation of vascular endothelial cells by targeting helicase with zinc finger 2. miR-ERIA offers a potential therapeutic target for diabetic cutaneous ulcers.

摘要

为了确定糖尿病皮肤溃疡的治疗靶点，需要了解细胞间的相互作用。我们研究了巨噬细胞衍生的晚期糖基化终产物（AGEs-EVs）处理后的细胞外囊泡，这种细胞外囊泡会抑制糖尿病皮肤伤口愈合。我们发现，一种富含于AGEs-EVs中的新型微小RNA（miR-ERIA）通过靶向锌指解旋酶2来抑制血管内皮细胞的迁移和管腔形成。miR-ERIA为糖尿病皮肤溃疡提供了一个潜在的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ec3/11926273/a26a26e103a3/db240701f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ec3/11926273/96d7a76fab23/db240701fGA.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ec3/11926273/37883e7e92ee/db240701f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ec3/11926273/24b89b7fbe75/db240701f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ec3/11926273/8cd690bb3794/db240701f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ec3/11926273/aea10a80dd54/db240701f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ec3/11926273/68576ff06ac8/db240701f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ec3/11926273/a26a26e103a3/db240701f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ec3/11926273/96d7a76fab23/db240701fGA.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ec3/11926273/37883e7e92ee/db240701f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ec3/11926273/24b89b7fbe75/db240701f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ec3/11926273/8cd690bb3794/db240701f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ec3/11926273/aea10a80dd54/db240701f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ec3/11926273/68576ff06ac8/db240701f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ec3/11926273/a26a26e103a3/db240701f6.jpg

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本文引用的文献

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J Extracell Vesicles. 2024 Feb;13(2):e12404. doi: 10.1002/jev2.12404.
2
The direct binding of bioactive peptide Andersonin-W1 to TLR4 expedites the healing of diabetic skin wounds.生物活性肽Andersonin-W1与Toll样受体4（TLR4）的直接结合加速糖尿病皮肤伤口的愈合。
Cell Mol Biol Lett. 2024 Feb 5;29(1):24. doi: 10.1186/s11658-024-00542-4.
3
Spatiotemporal single-cell transcriptomic profiling reveals inflammatory cell states in a mouse model of diffuse alveolar damage.
时空单细胞转录组分析揭示弥漫性肺泡损伤小鼠模型中的炎症细胞状态。
Exploration (Beijing). 2023 Apr 10;3(3):20220171. doi: 10.1002/EXP.20220171. eCollection 2023 Jun.
4
Role of exosome-derived miRNAs in diabetic wound angiogenesis.外泌体衍生 miRNA 在糖尿病创面血管生成中的作用。
Mol Cell Biochem. 2024 Oct;479(10):2565-2580. doi: 10.1007/s11010-023-04874-1. Epub 2023 Oct 27.
5
Dental pulp stem cells accelerate wound healing through CCL2-induced M2 macrophages polarization.牙髓干细胞通过CCL2诱导的M2巨噬细胞极化加速伤口愈合。
iScience. 2023 Sep 24;26(10):108043. doi: 10.1016/j.isci.2023.108043. eCollection 2023 Oct 20.
6
A frog peptide provides new strategies for the intervention against skin wound healing.一种青蛙肽为干预皮肤创伤愈合提供了新策略。
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JAMA. 2023 Jul 3;330(1):62-75. doi: 10.1001/jama.2023.10578.
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