细胞外囊泡相关的miR-ERIA在糖尿病伤口愈合中发挥巨噬细胞的抗血管生成作用。
Extracellular Vesicle-Associated miR-ERIA Exerts the Antiangiogenic Effect of Macrophages in Diabetic Wound Healing.
作者信息
Zeng Tingting, Sun Kan, Mai Lifang, Hong Xiaosi, He Xiaodan, Lin Weijie, Chen Sifan, Yan Li
机构信息
Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Guangdong Clinical Research Center for Metabolic Diseases, Guangzhou, China.
出版信息
Diabetes. 2025 Apr 1;74(4):596-610. doi: 10.2337/db24-0701.
An understanding of cell interactions is needed to identify therapeutic targets for diabetic cutaneous ulcers. We explored extracellular vesicles after treatment with advanced glycation end products (AGEs-EVs) derived from macrophages that can suppress diabetic cutaneous wound healing. We found that a novel miRNA enriched in AGEs-EVs (miR-ERIA) suppresses the migration and tube formation of vascular endothelial cells by targeting helicase with zinc finger 2. miR-ERIA offers a potential therapeutic target for diabetic cutaneous ulcers.
为了确定糖尿病皮肤溃疡的治疗靶点，需要了解细胞间的相互作用。我们研究了巨噬细胞衍生的晚期糖基化终产物（AGEs-EVs）处理后的细胞外囊泡，这种细胞外囊泡会抑制糖尿病皮肤伤口愈合。我们发现，一种富含于AGEs-EVs中的新型微小RNA（miR-ERIA）通过靶向锌指解旋酶2来抑制血管内皮细胞的迁移和管腔形成。miR-ERIA为糖尿病皮肤溃疡提供了一个潜在的治疗靶点。
Zotero 插件