Guo Shujin, Zhao Yingying, Yuan Yan, Liao Yang, Jiang Xuepan, Wang Lin, Lu Wei, Shi Jianyou
Department of Health Management Center, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Department of Geriatric Medicine, School of Medicine and Life Science, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Eur J Med Chem. 2025 Mar 15;286:117280. doi: 10.1016/j.ejmech.2025.117280. Epub 2025 Jan 13.
Macrophage migration inhibitory factor (MIF) functions as a critical cytokine regulating inflammatory and immune responses. Extensive research has demonstrated its involvement in the progression of various cancers, autoimmune diseases, and inflammatory disorders, establishing it as a pivotal target for anti-inflammatory and anticancer interventions. Therapeutic strategies aimed at MIF primarily focus on suppressing its activity through small molecule inhibitors and natural compounds. This review synthesizes current knowledge on MIF, encompassing its structural characteristics, enzymatic functions, signaling pathways, and roles in disease pathogenesis. Additionally, it provides an in-depth analysis of recent advancements in MIF inhibitor development, including design methodologies, structure-activity relationships, advanced eutectic analysis techniques, and key experimental findings. The discussion aims to support the development of safer, more effective, and highly selective small molecule inhibitors targeting MIF.
巨噬细胞移动抑制因子（MIF）作为一种关键的细胞因子，调节炎症和免疫反应。广泛的研究表明它参与了各种癌症、自身免疫性疾病和炎症性疾病的进展，使其成为抗炎和抗癌干预的关键靶点。针对MIF的治疗策略主要集中在通过小分子抑制剂和天然化合物抑制其活性。本综述综合了关于MIF的现有知识，包括其结构特征、酶功能、信号通路以及在疾病发病机制中的作用。此外，它还深入分析了MIF抑制剂开发的最新进展，包括设计方法、构效关系、先进的共晶分析技术和关键实验结果。讨论旨在支持开发更安全、更有效、高选择性的靶向MIF的小分子抑制剂。
