Liu Zhonghua, Xiao Tsan Sam
MOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, Hefei National Research Center for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.
Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
Cell. 2025 Jan 23;188(2):277-279. doi: 10.1016/j.cell.2024.12.030.
Plasma membrane rupture during lytic cell death was previously believed to occur through passive osmosis that burst open the membrane. Recent publications, including one in this issue of Cell, suggest that plasma membrane rupture is an active process mediated by ninjurin-1 (NINJ1) oligomers that dissolve membranes and/or assemble large pores.
在溶解性细胞死亡过程中，质膜破裂以前被认为是通过被动渗透作用使膜破裂。最近的一些出版物，包括本期《细胞》杂志上的一篇，表明质膜破裂是一个由ninjurin-1（NINJ1）寡聚体介导的主动过程，这些寡聚体溶解膜和/或组装大孔。
