Wang Zihan, Zhang Ruiqing, Zhang Yuanzhen, Xiong Yao, Zhang Ming
Reproductive Medicine Center, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, PR China; Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan 430071, Hubei Province, PR China; Wuhan Clinical Research Center for Reproductive Science and Birth Health, Wuhan 430071, Hubei Province, PR China.
Reproductive Medicine Center, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, PR China; Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan 430071, Hubei Province, PR China; Wuhan Clinical Research Center for Reproductive Science and Birth Health, Wuhan 430071, Hubei Province, PR China.
NanoImpact. 2025 Jan;37:100545. doi: 10.1016/j.impact.2025.100545. Epub 2025 Jan 22.
Long-term effects of microplastics (MPs) exposure have been demonstrated to impair reproductive function. However, in real world, the exposure level of MP is not constant and it may vary in different individuals. This study aims to evaluate the impact of short-term exposure to MPs on ovarian and endometrial function in rat models. Serum steroid hormone concentrations and the expression of ovarian steroid hormone receptor were disturbed. We found that as MPs exposure concentration increased, thickness of the endometrial glandular epithelial layer and the number of endometrial glands decreased; the number of primordial follicles decreased, while the numbers of primary and secondary oocytes significantly increased, indicating a potential oocyte overactivation. Although short-term MP exposure appears to not influence embryo implantation and hormone functions, the results of this study highlight the potential of MPs to disrupt reproductive health in women.
已证实微塑料（MPs）暴露的长期影响会损害生殖功能。然而，在现实世界中，MP的暴露水平并非恒定不变，且在不同个体中可能存在差异。本研究旨在评估大鼠模型短期暴露于MPs对卵巢和子宫内膜功能的影响。血清类固醇激素浓度和卵巢类固醇激素受体的表达受到干扰。我们发现，随着MPs暴露浓度的增加，子宫内膜腺上皮层厚度和子宫内膜腺体数量减少；原始卵泡数量减少，而初级和次级卵母细胞数量显著增加，表明存在潜在的卵母细胞过度激活。尽管短期MP暴露似乎不影响胚胎着床和激素功能，但本研究结果凸显了MPs对女性生殖健康造成破坏的可能性。
