Granieri E, Tola R, Paolino E, Rosati G, Carreras M, Monetti V C
Ann Neurol. 1985 Jan;17(1):80-4. doi: 10.1002/ana.410170117.
Results of intensive prevalence surveys on multiple sclerosis carried out in different small regions of Italy have suggested that this country falls into the high-frequency zone for the disease. To verify this hypothesis by studying a large population, we conducted intensive incidence and prevalence survey in the province of Ferrara, northern Italy (mean population, 386,000). Based on 128 patients, the mean incidence per year for the period 1965 through 1979 was 2.2 cases per 100,000. On October 24, 1981, the prevalence rate was 46.1 cases per 100,000. The results support the view that northern Italy is a high-risk area for multiple sclerosis.
在意大利不同小区域进行的多发性硬化症密集患病率调查结果表明，该国属于该疾病的高频区。为了通过研究大量人群来验证这一假设，我们在意大利北部费拉拉省（平均人口38.6万）进行了密集的发病率和患病率调查。基于128名患者，1965年至1979年期间的年平均发病率为每10万人2.2例。1981年10月24日，患病率为每10万人46.1例。结果支持了意大利北部是多发性硬化症高风险地区这一观点。
