Li Xiangyue, Huang Xuemei, Yu Xiaolan
Department of Obstetrics and Gynecology, Southwest Medical University, Luzhou, China.
Department of Oncology and Hematology, Southwest Medical University, Luzhou, China.
BMC Pregnancy Childbirth. 2025 Jan 24;25(1):69. doi: 10.1186/s12884-024-07063-0.
Behçet's disease (BD) during pregnancy is a relatively rare condition, and there are currently no established guidelines for its management. The effects of BD on both mothers and children remain unclear. In this paper, we present the diagnostic and treatment processes for a patient with BD during pregnancy.
A 20-year-old woman, gravida 2, para 1, presented to our inpatient department with recurrent oral and genital ulcers at 28 weeks and 3 days of gestation. Given the complexity of the patient's condition, we initiated the first multidisciplinary consultation to establish appropriate treatment regimens. However, the initial treatment was ineffective, and the patient experienced a fever for four days. Consequently, we conducted a second multidisciplinary consultation. The final treatment regimen included azithromycin, hydroxychloroquine, prednisone, and low-molecular-weight heparin calcium. The clinical symptoms resolved, and the female neonate was delivered successfully. No relapse was observed during the four-month follow-up.
The critical issues in treatment involve ensuring medication safety for pregnant women and preventing adverse pregnancy outcomes. Notably, one potential cause of adverse pregnancy outcomes in individuals with BD is vasculopathy, which necessitates prompt treatment with anticoagulant therapy. Obstetricians should closely monitor disease progression and remain vigilant for complications in order to minimize adverse outcomes during pregnancy.
妊娠期间的白塞病（BD）是一种相对罕见的病症，目前尚无既定的管理指南。BD对母亲和孩子的影响仍不明确。在本文中，我们介绍了一名妊娠期间患有BD的患者的诊断和治疗过程。
一名20岁女性，孕2产1，在妊娠28周零3天时因复发性口腔和生殖器溃疡入住我院住院部。鉴于患者病情复杂，我们启动了首次多学科会诊以制定合适的治疗方案。然而，初始治疗无效，患者发热四天。因此，我们进行了第二次多学科会诊。最终治疗方案包括阿奇霉素、羟氯喹、泼尼松和低分子肝素钙。临床症状缓解，女婴成功分娩。在四个月的随访期间未观察到复发。
治疗中的关键问题包括确保孕妇用药安全和预防不良妊娠结局。值得注意的是，BD患者不良妊娠结局的一个潜在原因是血管病变，这需要及时进行抗凝治疗。产科医生应密切监测疾病进展并对并发症保持警惕，以尽量减少妊娠期间的不良结局。
