Zabolotneva Anastasia A, Popruga Katerina E, Makarov Valentin V, Yudin Sergei M, Gaponov Andrei M, Roumiantsev Sergei A, Shestopalov Aleksandr V
Department of Biochemistry and Molecular Biology, Faculty of Medicine, FSAEI HE N. I. Pirogov Russian National Research Medical University of MOH of Russia, 1 Ostrovitianov Str., 117997 Moscow, Russia.
Center for Strategic Planning and Management of Medical and Biological Health Risks of FMBA of Russia; Pogodinskya Str., h.10, b.1, 119121 Moscow, Russia.
Biomedicines. 2025 Jan 13;13(1):183. doi: 10.3390/biomedicines13010183.
Disorders of glucose and lipid metabolism, such as obesity, diabetes mellitus, or hypercholesterolemia, can cause serious complications, reduce quality of life, and lead to increased premature mortality. Olivetol, a natural compound, could be proposed as a promising therapeutic agent for preventing, treating, or alleviating metabolic complications of such pathological conditions.
In this study, the researchers conducted a broad parallel investigation of olivetol's effects on metabolic state and gut microbiota functionality in mouse models of alimentary obesity, diabetes mellitus type 1 and 2, and hypercholesterolemia.
According to the results of the study, olivetol caused a lowering of body weight in C57Bl6 mice fed a high-fat diet and in (-/-) mice, decreased serum glucose levels in / mice, improved lipid metabolism in (-/-) mice, and prevented inflammatory infiltration of the pancreas and loss of insulin secretion in NOD mice. In addition, olivetol affected the composition and functional activity of gut microbiota communities, inducing an expansion of probiotic species such as and and depleting the representation of pathobionts such as , although olivetol supplementation did not influence the diversity or richness of the communities.
These results suggest that olivetol is a promising therapeutic agent for preventing, treating, or alleviating the metabolic complications of obesity, diabetes mellitus type 1 and 2, and hypercholesterolemia; however, more investigations are required in order to attain a full understanding of its physiological effects.
葡萄糖和脂质代谢紊乱，如肥胖、糖尿病或高胆固醇血症，可导致严重并发症，降低生活质量，并导致过早死亡率增加。橄榄醇是一种天然化合物，有望作为预防、治疗或缓解此类病理状况代谢并发症的治疗剂。
在本研究中，研究人员对橄榄醇在饮食性肥胖、1型和2型糖尿病以及高胆固醇血症小鼠模型中对代谢状态和肠道微生物群功能的影响进行了广泛的平行研究。
根据研究结果，橄榄醇可使高脂饮食喂养的C57Bl6小鼠和（-/-）小鼠体重降低，使/小鼠血清葡萄糖水平降低，改善（-/-）小鼠的脂质代谢，并防止NOD小鼠胰腺的炎症浸润和胰岛素分泌丧失。此外，橄榄醇影响肠道微生物群落的组成和功能活性，诱导益生菌种类如和的扩增，并减少病原菌如的数量，尽管补充橄榄醇不影响群落的多样性或丰富度。
这些结果表明，橄榄醇有望作为预防、治疗或缓解肥胖、1型和2型糖尿病以及高胆固醇血症代谢并发症的治疗剂；然而，为了全面了解其生理作用，还需要进行更多的研究。
