Weisberg L A
Arch Neurol. 1985 Apr;42(4):336-41. doi: 10.1001/archneur.1985.04060040046010.
Seventeen patients with computed tomographic (CT) evidence of a solitary cerebellar metastasis were studied. In 11 of 17 cases, neurologic symptoms preceded systemic evidence of carcinoma. Initial neurologic symptoms included gait instability (13 cases) and headache and vomiting (four cases). All patients had evidence of gait or limb ataxia on neurologic examination. Fourteen patients underwent craniotomy and subsequent irradiation, and three had radiotherapy without initial surgical biopsy. One patient with lung carcinoma had clinical and CT evidence of intracranial recurrence 14 months later but no evidence of widespread systemic carcinoma. Fifteen patients later showed evidence of systemic carcinoma but then died without subsequent development of recurrent cerebellar dysfunction or other neurologic abnormalities. Furthermore, in six of these patients with widespread systemic carcinoma, scans taken two to six months after completion of surgery and/or radiation therapy for the solitary metastasis showed no evidence of recurrent intracranial disease.
对17例有计算机断层扫描（CT）证据显示存在孤立性小脑转移瘤的患者进行了研究。17例中有11例，神经系统症状先于癌症的全身证据出现。最初的神经系统症状包括步态不稳（13例）以及头痛和呕吐（4例）。所有患者在神经系统检查中均有步态或肢体共济失调的表现。14例患者接受了开颅手术及后续放疗，3例未进行初始手术活检直接接受了放疗。1例肺癌患者在14个月后出现颅内复发的临床及CT证据，但无广泛全身癌的证据。15例患者后来出现了全身癌的证据，但随后死亡，未再发生复发性小脑功能障碍或其他神经系统异常。此外，在这15例有广泛全身癌的患者中，6例在针对孤立转移瘤完成手术和/或放疗后两至六个月进行的扫描显示，没有颅内疾病复发的证据。
