Jafri Zuhayr, Li Yue, Zhang Jingwen, O'Meara Connor H, Khachigian Levon M
Vascular Biology and Translational Research, Department of Pathology, School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia.
Division of Head & Neck Oncology and Microvascular Reconstruction, Department of Otolaryngology, Head & Neck Surgery, University of Virginia Health Services, Charlottesville, VA 22903, USA.
Int J Mol Sci. 2025 Jan 10;26(2):555. doi: 10.3390/ijms26020555.
Jun/JUN is a basic leucine zipper (bZIP) protein and a prototypic member of the activator protein-1 (AP-1) family of transcription factors that can act as homo- or heterodimers, interact with DNA elements and co-factors, and regulate gene transcription. Jun is expressed by both immune and inflammatory cells. Jun is traditionally seen as an oncoprotein that regulates processes involved in transformation and oncogenesis in human tumours. This article examines the traditional view that Jun plays a permissive role in cancer development and progression, whilst exploring emerging evidence supporting Jun's potential to prevent immune cell exhaustion and promote anti-tumour efficacy.
Jun/JUN是一种碱性亮氨酸拉链（bZIP）蛋白，也是转录因子激活蛋白-1（AP-1）家族的原型成员，它可以形成同二聚体或异二聚体，与DNA元件和辅因子相互作用，并调节基因转录。Jun在免疫细胞和炎症细胞中均有表达。传统上，Jun被视为一种癌蛋白，可调节人类肿瘤中与转化和肿瘤发生相关的过程。本文审视了Jun在癌症发展和进展中起许可作用的传统观点，同时探讨了支持Jun具有预防免疫细胞耗竭和提高抗肿瘤疗效潜力的新证据。
