Alicia López-Biedma, María Ángeles Onieva-García, Desirée Martín-García, Maximino Redondo, Marilina García-Aranda
Research and Innovation Unit, Hospital Costa del Sol, Autovía A-7 km 187, 29603 Marbella, Spain.
Instituto de Investigación Biomédica de Málaga-Plataforma BIONAND (IBIMA-BIONAND), Severo Ochoa, 35, 29590 Malaga, Spain.
Int J Mol Sci. 2025 Jan 14;26(2):653. doi: 10.3390/ijms26020653.
COVID-19 has been a challenge at the healthcare level not only in the early stages of the pandemic, but also in the subsequent appearance of long-term COVID-19. Several investigations have attempted to identify proteomic biomarkers in an attempt to improve clinical care, guide treatment and predict possible patient outcomes. Proteins such as C-reactive protein (CRP) or interleukin 6 (IL-6) are clear markers of severe disease, but many others have been proposed that could help in risk stratification and in the prediction of specific complications. This review aims to bring together the most relevant studies in this regard, providing information to identify the most notable biomarkers in relation to COVID-19 found to date.
新型冠状病毒肺炎(COVID-19)不仅在疫情早期对医疗保健层面构成了挑战,在随后出现的长期COVID-19阶段也是如此。多项研究试图鉴定蛋白质组学生物标志物,以改善临床护理、指导治疗并预测患者可能的预后。诸如C反应蛋白(CRP)或白细胞介素6(IL-6)等蛋白质是严重疾病的明确标志物,但也有人提出了许多其他可能有助于风险分层和特定并发症预测的标志物。本综述旨在汇总这方面最相关的研究,提供信息以识别迄今为止发现的与COVID-19相关的最显著生物标志物。