肯尼亚“新冠后遗症”患者的临床特征、抗 SARS-CoV-2 IgG 滴度和炎症标志物：一项横断面研究。

Clinical characteristics, anti-SARS-CoV-2 IgG titers, and inflammatory markers in individuals with post-COVID-19 condition in Kenya: a cross-sectional study.

机构信息

Department of Medical Laboratory Science, Kenyatta University, Nairobi, Kenya.

Department of Medical Microbiology and Parasitology, Kenyatta University, Nairobi, Kenya.

出版信息

PeerJ. 2024 Jul 22;12:e17723. doi: 10.7717/peerj.17723. eCollection 2024.

DOI:10.7717/peerj.17723

PMID:39056056

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11271650/

Abstract

BACKGROUND

Post-coronavirus disease 2019 (post-COVID-19) is associated with considerable morbidity and reduced quality of life. However, studies characterizing the post-COVID-19 condition in Kenya are limited. This study aimed to determine the prevalence of post-COVID-19 condition and determine the clinical characteristics, anti-SARS-CoV-2 IgG titers, and concentrations of inflammatory markers of individuals with post-COVID-19 condition in Kenya.

METHODS

This descriptive cross-sectional study was conducted at the Kenyatta University Health Unit, Kenya. Demographic and clinical data were collected using a questionnaire. The serum levels of anti-SARS-CoV-2 antibodies, interleukin 6 (IL-6), and C-reactive protein (CRP) were quantified by enzyme-linked immunosorbent assays. Independent samples t-test was used to compare the anti-SARS-CoV-2 IgG, IL-6, and CRP levels between the participants with and without post-COVID-19 symptoms. The case definition for post-COVID-19 condition was persistence of acute COVID-19 symptoms or emergence of new symptoms 3 months after COVID-19 diagnosis, symptoms lasting for ≥2 months, and absence of any other etiological basis to explain the symptoms.

RESULTS

A total of 189 volunteers were recruited in this study (median age: 21 years, range: 18-71 years; male, 49.2%). Forty participants reported having had at least one COVID-19 positive diagnosis in the past, of which 12 (30%) complained of post-COVID-19 symptoms. Significant differences in the number and duration of symptoms were observed between the individuals with and without post-COVID-19 symptoms (-statistic = 2.87, = 0.01; -statistic = 2.39, = 0.02, respectively). However, no significant differences in serum levels of anti-SARS-CoV-2 IgG, IL-6, and CRP were observed between the two groups ( = 0.08, 0.9, and 0.28, respectively).

CONCLUSION

These findings suggest that post-COVID-19 condition is a health concern even for a relatively young population in Kenya and globally. This condition requires more attention and well-designed studies to better define it and identify clinical chemistry markers that can be used for its diagnosis.

摘要

背景

新冠病毒病 2019 后(post-COVID-19)与相当大的发病率和生活质量下降有关。然而，描述肯尼亚新冠病毒病 2019 后(post-COVID-19)状况的研究有限。本研究旨在确定肯尼亚 post-COVID-19 状况的患病率，并确定具有 post-COVID-19 状况个体的临床特征、抗 SARS-CoV-2 IgG 滴度和炎症标志物浓度。

方法

本描述性横断面研究在肯尼亚肯雅塔大学卫生单位进行。使用问卷收集人口统计学和临床数据。通过酶联免疫吸附试验定量测定血清抗 SARS-CoV-2 抗体、白细胞介素 6 (IL-6)和 C 反应蛋白 (CRP)的水平。采用独立样本 t 检验比较有和无 post-COVID-19 症状患者的抗 SARS-CoV-2 IgG、IL-6 和 CRP 水平。post-COVID-19 状况的病例定义为急性 COVID-19 症状持续或 COVID-19 诊断后 3 个月出现新症状、症状持续≥2 个月且无任何其他病因解释症状。

结果

本研究共招募了 189 名志愿者(中位数年龄：21 岁，范围：18-71 岁；男性，49.2%)。40 名志愿者报告过去至少有一次 COVID-19 阳性诊断，其中 12 名(30%)有 post-COVID-19 症状。有和无 post-COVID-19 症状患者的症状数量和持续时间存在显著差异(-统计量=2.87， =0.01；-统计量=2.39， =0.02)。然而，两组间抗 SARS-CoV-2 IgG、IL-6 和 CRP 的血清水平无显著差异( =0.08、0.9 和 0.28)。